Brevican Mouse, Unlabeled, Clone: 2, BD

Description

• Neural tissue expresses a variety of cell surface heparan sulfate and extracellular chondroitin sulfate containing proteoglycans
• Brevican, a chondroitin sulfate proteoglycan, is a member of the lectican family
• Other members of this family are aggrecan, versican, and neurocan
• These proteins are either heparan sulfate or keratan sulfate containing glycosylphosphatidylinositol (GPI) anchored or membrane spanning proteoglycans, or soluble chondroitin sulfate containing proteoglycans
• Brevican exists as either a soluble or GPI-anchored plasma membrane protein
• Brevican contains the shortest core protein of any of the family members
• In addition, it is characterized by chondroitin sulfate chains, an N-terminal hyaluronic acid-binding domain (HA), an epidermal growth factor-like (EGF) repeat, and lectin-like and complement regulatory protein-like domains in its C-terminal region
• Primary cerebellar astrocytes are the major site for mRNA expression and little, if any, is found in neurons
• Although there is an 80 kDa N-terminal truncated form, full length brevican can be up to 145 kDa
• Brevican is thought to play a role in the terminal differentiation and regulation of the adult nervous system.