TGN38 Mouse anti-Rat, Unlabeled, Clone: 2, BD

Description

• Newly synthesized proteins exit the ER and move to the cis-Golgi network (CGN) where they traverse the cis-medial and trans-cisternae before reaching the trans-Golgi network (TGN)
• N-linked oligosaccharide processing occurs in the TGN, and proteins are sorted to the plasma membrane, lysosomes, endosomes, and secretory granules
• TGN38 is a type I integral membrane protein primarily localized to the TGN
• It is involved in the sorting of nascent proteins into individual carrier vesicles for transport to appropriate destinations
• It is thought to heterodimerize with TGN41 and participate in exocytic budding from the TGN
• TGN38 has a molecular weight of 85 to 95kDa
• The core polypeptide represents approximately 38kDa, while the remainder is accounted for by N- and O-linked oligosaccharide chains
• A 286 aa N-terminal lumenal domain, a 21 aa membrane spanning domain, and a 33 aa C-terminal cytoplasmic tail comprise the structure of TGN38
• The cytoplasmic tail contains a tyrosine-based motif, YQRL, that is thought to be involved in TGN localization
• Therefore, TGN38 mediates the localization of various proteins to the TGN and serves as a TGN retrieval signal
• Immunofluorescence, Western Blotting