mGluR1 Mouse, Unlabeled, Clone: 20, BD

Description

• Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS
• The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic
• Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction
• Eight metabotropic glutamate receptors (mGluR1-8) and several Ca 2+ sensing receptors belong to a novel G-protein coupled receptor (GPCR) family
• The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins
• However, they exhibit no additional sequence homology to any member of other GPCR families
• mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains
• The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site
• mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca 2+ ; mobilization necessary for many signal transduction events
• Immunofluorescence, Western Blotting