CD51 Mouse, Unlabeled, Clone: 21, BD

Description

• Integrins are a family of proteins that mediate intercellular adhesion or adherence to extracellular matrix proteins
• Their roles are essential for embryonic development, tumor metastasis, organ function, and proper immune cell function
• Family members are heterodimers that contain a larger α subunit that is unique to each individual receptor and a smaller β subunit that can be shared by several receptors
• Based on β subunit content, integrins are divided into the subfamilies β1, β2, and β3
• The β3 subfamily contains the vitronectin receptor (αVβ3) and the platelet protein gpIIb/IIIa
• The α chain of the vitronectin receptor (VNRα, CD51, integrin αV) has been reported to consist of a disulfide-linked large extracellular (125kDa) subunit and a smaller (25kDa) membrane-anchored subunit
• The large subunit contains multiple sequences with homology to calcium-binding sites in other proteins and an RGD-dependent ligand-binding site, while the small subunit contains a transmembrane domain and a short cytoplasmic domain
• VNRα has been reported to be noncovalently associated with the VNR β3-chain (CD61, gpIIIa)
• The VNR mediates cell adhesion to RGD-containing ligands such as vitronectin, von Willebrand factor, fibrinogen, and thrombospondin
• Immunofluorescence, Western Blotting