Oct3/4 Mouse, Unlabeled, Clone: 40/OCT-3, BD

Description

• Development of a multicellular organism from a single fertilized cell is regulated by the coordinated activity of DNA transcription factors
• Oct3/4, a member of the POU family of transcription factors, functions in pluripotent cells of early embryonic stem cell (ES) lines and embryonal carcinomas (EC)
• Other members of the POU family include Oct1, Oct2, Pit-1, and unc-86
• The POU domain, a 150-amino acid region that determines binding specificity, is conserved among these proteins and consists of 3 subdomains: POU-specific A and B subdomains and a homeobox-like subdomain
• Oct3/4 is expressed in undifferentiated cells, but is lost as cells are induced to differentiate
• Oct3/4 is not expressed in adult tissues
• The interaction of Oct3/4 with SOX2, another embryonic transcription factor, produces an active complex that regulates expression of genes such as Nanog, UTF1, and FGF4
• Although Oct3/4 is specifically phosphorylated on serine residues, this modification is not required for DNA binding, but may affect its transactivation potential
• Thus, Oct3/4 is a transcription factor that plays an important role in determining early steps of embryogenesis and differentiation
• Host Species: Mouse Clone: 40 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Mouse Oct3 aa
• 252-372 Recombinant Protein Formula Weight [Chemical]: 46kDa Western Blotting