BDB611222

Tim23 Mouse, Unlabeled, Clone: 32, BD

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB611222-Each-of-1 In Stock ₹ 24,598.50

BDB611222 - Each of 1

₹ 24,598.50

In Stock

Quantity

1

Base Price: ₹ 24,598.50

GST (18%): ₹ 4,427.73

Total Price: ₹ 29,026.23

Antigen

Tim23

Classification

Monoclonal

Concentration

250μg/mL

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Immunogen

Rat Tim23 aa. 5-126

Quantity

50 μg

Research Discipline

Cell Biology

Target Species

Human, Mouse, Rat

Isotype

IgG2a

Applications

Western Blot

Clone

32

Conjugate

Unconjugated

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

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Description

  • Mitochondria, the site of cellular energy production, must import all proteins necessary for their function
  • Import is mediated by two mechanisms: the translocase of the outer membrane (Tom) and the translocase of the inner membrane (Tim)
  • Tim23 and Tim17 are integral membrane proteins that associate to form the import channel for mitochondrial preproteins that contain N-terminal hydrophilic sequences
  • They also associate with Tim44, an adaptor for the membrane binding of mtHsp70, a matrix heat shock protein, which drives the import of the processed preprotein
  • The N-terminal intermembrane space domain of Tim23 contains a leucine zipper motif and mediates the formation of a Tim23 dimer
  • As an imported protein passes through the TOM machinery, its N-terminal matrix targeting sequence interacts with the Tim23 dimer
  • This induces the dissociation of the dimer and initiation of inner membrane translocation of the presequence
  • In addition to its 9kDa N-terminal hydrophilic segment, Tim23 contains a 14kDa hydrophobic domain with four predicted membrane spans
  • Thus, Tim23 is an important integral membrane component of the mitochondrial protein translocation machinery
  • Host Species: Mouse Clone: 32 Isotype: IgG2a Species Reactivity: Mouse Immunogen: Rat Tim23 aa
  • 5-126 Formula Weight [Chemical]: 23kDa Immunofluorescence, Western Blotting

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Antigen:
Tim23

Classification:
Monoclonal

Concentration:
250μg/mL

Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Immunogen:
Rat Tim23 aa. 5-126

Quantity:
50 μg

Research Discipline:
Cell Biology

Target Species:
Human, Mouse, Rat

Isotype:
IgG2a

Applications:
Western Blot

Clone:
32

Conjugate:
Unconjugated

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at -20°C.

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Antigen:
Tim23

Classification:
Monoclonal

Concentration:
250μg/mL

Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Immunogen:
Rat Tim23 aa. 5-126

Quantity:
150 μg

Research Discipline:
Cell Biology

Target Species:
Human, Mouse, Rat

Isotype:
IgG2a

Applications:
Western Blot

Clone:
32

Conjugate:
Unconjugated

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at -20°C.

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Concentration:
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Formulation:
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Immunogen:
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Quantity:
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Research Discipline:
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Conjugate:
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Host Species:
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Store undiluted at -20°C.

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Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Immunogen:
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Quantity:
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Research Discipline:
Cell Biology

Target Species:
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Isotype:
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Applications:
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Clone:
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Conjugate:
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Purification Method:
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Regulatory Status:
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Primary or Secondary:
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