Tim23 Mouse, Unlabeled, Clone: 32, BD

Description

• Mitochondria, the site of cellular energy production, must import all proteins necessary for their function
• Import is mediated by two mechanisms: the translocase of the outer membrane (Tom) and the translocase of the inner membrane (Tim)
• Tim23 and Tim17 are integral membrane proteins that associate to form the import channel for mitochondrial preproteins that contain N-terminal hydrophilic sequences
• They also associate with Tim44, an adaptor for the membrane binding of mtHsp70, a matrix heat shock protein, which drives the import of the processed preprotein
• The N-terminal intermembrane space domain of Tim23 contains a leucine zipper motif and mediates the formation of a Tim23 dimer
• As an imported protein passes through the TOM machinery, its N-terminal matrix targeting sequence interacts with the Tim23 dimer
• This induces the dissociation of the dimer and initiation of inner membrane translocation of the presequence
• In addition to its 9kDa N-terminal hydrophilic segment, Tim23 contains a 14kDa hydrophobic domain with four predicted membrane spans
• Thus, Tim23 is an important integral membrane component of the mitochondrial protein translocation machinery
• Host Species: Mouse Clone: 32 Isotype: IgG2a Species Reactivity: Mouse Immunogen: Rat Tim23 aa
• 5-126 Formula Weight [Chemical]: 23kDa Immunofluorescence, Western Blotting