α-Synuclein Mouse, Unlabeled, Clone: 42, BD

Description

• Synuclein cDNA was isolated from Torpedo californica and found to encode a 143 amino acid neuron-specific protein
• In addition, a rat brain cDNA library yielded several clones that encode different proteins with homology to Torpedo Synuclein
• A 140 amino acid protein in rat is referred to as Synuclein-1
• In situ hybridization shows synuclein mRNAs in discrete areas of rat brain, notably the hippocampus
• In humans, two synuclein proteins of 140 and 134 amino acids were sequenced that exhibit a high degree of homology with each other (61% identity) and with previously described Synuclein proteins
• The 140 amino acid protein (α-Synuclein) is the human homologue of rat Synuclein-1 and is identical to the non-amyloid-β component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD)
• The 134 amino acid protein (β-Synuclein) is the human homologue of bovine phosphoneuroprotein
• These proteins are expressed in brain, primarily in presynaptic nerve terminals
• Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease
• Immunofluorescence, Immunoprecipitation, Western Blotting