Plakophilin 2 Mouse anti-Human, Unlabeled, Clone: 28, BD

Description

• Plakophilin 2 is a desmosomal plaque protein that belongs to the “arm” repeat family of proteins
• Alternative splicing results in two isoforms: 2a (837 aa) and 2b (881 aa)
• The 2b isoform contains an insertion of 44 aa in the arm repeat unit 2
• Other arm family members are β-catenin, plakophilin 1, plakoglobin, pp120, and armadillo of Drosophila gene product
• They have at least 9 repeats of the arm motif, which consists of approximately 42 aa, and a short carboxyl terminus
• Plakophilins are constitutively expressed in desmosome-containing cells
• Plakophilin 1 has been found only in desmosomal-containing cells, such as stratified and complex epithelia
• Plakophilin 2 has been isolated from both desmosomal as well as non-desmosomal forming cells, including simple and glandular epithelia, and from nonepithelial tissues such as the mycocardium and Purkinje fibers
• In addition, Plakophilin 2 is found in the karyoplasm of interphase cells
• Plakophilins 2a and 2b are part of desmosomal plaques, although they are located primarily in the karyoplasm of the interphase nucleus
• The function of nuclear plakophilin 2 remains to be identified
• Immunofluorescence, Immunoprecipitation, Western Blotting