UBE3A Mouse, Unlabeled, Clone: 13, BD

Description

• Protein ubiquitination is the end product of a multienzyme cascade that involves sequential thiol-ester bond interactions between ubiquitin and enzymes termed E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin protein ligases
• UBE3A (human papilloma virus E6-associated protein; E6-AP) is an E3 ubiquitin protein ligase that is linked to the neurological disorder Angelman syndrome
• It mediates the interaction of human papilloma virus types 16 and 18 E6 proteins with p53, which targets p53 to the ubiquitination-proteasome degradation pathway
• The C-terminal region of UBE3A contains a hect domain, which is found in many E3 ubiquitin protein ligases, while the central region contains an E6 binding region
• UBE3A is expressed in the cytoplasm and nucleus of many tissues
• The interaction of UBE3A with the progesterone receptor coactivates transciptional activity of the receptor in the presence of bound hormone
• Thus, UBE3A is an essential component of the ubiquitination degradation pathway and the nuclear hormone receptor signal transduction pathways
• Host Species: Mouse Clone: 13 Isotype: IgG1 Species Reactivity: Human Immunogen: Mouse UBE3A aa
• 501-712 Formula Weight [Chemical]: 100kDa Immunofluorescence, Western Blotting