KIF3A Mouse, Unlabeled, Clone: 28, BD

Description

• The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division
• Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein
• A family of N-terminal motor domain kinesin proteins includes KIF3A/3B, KRP85/95, and Klp68d/64
• These proteins form heterodimeric two-headed motors that interact with kinesin associated protein (KAP)
• The KIF3A/3B/KAP3 heterotrimeric motor has plus-end directed microtubule sliding activity
• This heterotrimeric motor is expressed ubiquitously and is used for anterograde transport of membranous organelles
• KIF3A- and KIF3B-deficient mice have defects in the formation of the cilia located in the embryonic node
• In addition, KIF3A localizes to the basal body of the connecting cilium axoneme and to vesicles at the pre-synaptic ribbon in photoreceptor cells
• Thus, KIF3 motors are involved in microtubule-based formation and movement of cilia and the transport of synaptic vesicles
• Host Species: Mouse Clone: 28 Isotype: IgG1 Species Reactivity: Rat Immunogen: Human KIF3A aa
• 563-671 Formula Weight [Chemical]: 80/85kDa Immunofluorescence, Western Blotting