S100B Mouse, Unlabeled, Clone: 19, BD

Description

• The S100 multigene family consists of a number of small dimeric molecules around 100 residues in length
• The original members of this family, S100A and S100B, were initially identified in bovine brain
• Other S100 proteins have also been identified, such as S100P from human placenta and S100L from bovine lung
• The S100 family consists of at least 10 members which show a cell-type-specific expression pattern
• Most S100 proteins are believed to be involved in Ca 2+ ; signaling pathways
• S100P consists of 95 amino acids and shares about 50% sequence identity with S100A and S100B, while S100L has been shown to possess 43-47% homology to S100A and S100B
• S100B is expressed in the nervous system by glial cells, such as astrocyte, oligodendroglial, ependymal, and microglial cells
• The dimeric form of S100B has been implicated in neuronal survival, neurite extension, and astrocyte growth
• In addition, S100B expression is induced by stimulations that activate p53, and S100B activity may be involved in PKC-dependent p53 nuclear translocation in early G1 phase
• Thus, S100B plays a role in calcium signaling pathways that regulate cell differentiation and cell cycle progression
• Immunofluorescence, Western Blotting