BMPR-II Mouse, Unlabeled, Clone: 18, BD

Description

• The transforming growth factor β (TGFβ)/activin/BMP family of growth factor plays a diverse and important role in growth, development, and differentiation
• The receptors for this famiy of proteins are type I and II ser/thr kinase receptors
• Bone morphogenetic protein receptors (BMPRs) include two type I receptors, BMPR-IA and BMPR-IB, and a type II receptor, BMPR-II
• BMPR-II is a widely expressed receptor, with high mRNA expression during development in many tissues
• BMPR-II transfected COS-1 cells show binding to BMP-7 (osteogenic protein-1) and BMP-4, and co-transfection with the type I receptor, ActR-I, leads to transcriptional activation in response to BMP-7
• In addition, extracellular matrix proteins may regulate the expression of BMPR-II during angiogenesis, since fibrillar type I collagen induces BMPR-II expression in endothelial cells
• In familial primary pulmonary hypertension, the BMPR-II gene is mutated in a manner that may disrupt ligand binding, kinase activity, and heteromeric dimer formation
• Thus, BMPR-II may be an important mediator of BMP effects during growth and differentiation of endothelial cells.