MTP Mouse, Unlabeled, Clone: 8, BD

Description

• The microsomal triglyceride transfer protein (MTP) catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between membranes within the lumen of microsomes in hepatocytes and enterocytes
• MTP forms a heterodimer with the 58kDa protein disulfide isomerase
• PDI catalyzes the isomerization of intramolecular disulfide bridges, thereby allowing them to generate their most thermodynamically stable configuration within proteins
• MTP is mutated in abetalipoproteinemia, which results from defects in apolipoprotein-B (apoB)-containing lipoproteins
• A lack of MTP expression prevents secretion of apoB from mammalian cells, leading to intracellular degradation
• In the C-terminal region, MTP has structural homology to apoB and the lamprey lipovitellin protein
• This region contains a membrane binding helix (Helix A), and a triglyceride binding helix (Helix B)
• Mutations in Helix B cause abetalipoproteinemia
• In addition, inhibitors of MTP activity may be important therapeutics for lowering atherogenic lipoprotein levels
• Thus, MTP is a microsomal protein that is required for transport of lipids between membranes in liver and small intestines
• Host Species: Mouse Clone: 8 Isotype: IgG2a Species Reactivity [for Features Main]: Mouse Immunogen: Mouse MTP aa
• 91-288 Immunofluorescence, Western Blotting