Serine Racemase Mouse, Unlabeled, Clone: 29, BD

Description

• The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation
• Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic
• The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate
• NMDA receptors require coactivation at both glutamate and glycine sites
• D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors
• D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5′ phosphate (PLP)-dependent enzyme family
• Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells
• Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function
• Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission
• Host Species: Mouse Clone: 29 Isotype: IgG1 Species Reactivity [for Features Main]: Mouse Immunogen: Mouse serine racemase aa
• 127-248 Immunofluorescence, Western Blotting