BAF47 Mouse, Unlabeled, Clone: 25, BD

Description

• SWI/SNF complexes facilitate gene activation and transcription factor binding by altering repressive chromatin structures in an ATP-dependent manner
• In mammals, SWI/SNF complexes are present in mutliple forms that include 9-12 BRG1-associated factors (BAFs) per complex
• These BAF proteins range in molecular weight from 47 to 250kDa
• BAF47/SNF5 (SMARCB1/Ini1) complexes with BRG1- and BRM-containing SWI/SNF complexes
• BAF47/SNF5 mRNA is widely expressed in cell lines and tissues, and BAF47/SNF5 gene is mutated in many human tumors
• The latter is indicative of a tumor suppressor role for BAF47/SNF5
• In addition, mice deficient for BAF47 die early in embryogenesis, while BAF47/SNF5 heterozygous mice display a variety of tumors in the soft tissues of the head and neck
• BAF47/SNF5 also binds the HIV-1 integrase and stimulates integrase-mediated DNA joining activity
• Thus, BAF47/SNF5 is a component of SWI/SNF complexes that may be critical for normal development and tumor suppression, but may also be a protein utilized for viral DNA integration into host DNA
• Western Blotting