CtBP1 (C-terminal Binding Protein-1) Mouse, Unlabeled, Clone: 3, BD

Description

• Transcriptional repression is critical for genetic regulation of many cellular proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a corepressor can bind
• C-terminal binding proteins (CtBP1 and CtBP2) are a class of corepressors that interact with a subset of transcription factors through a PLDLSL sequence motif
• CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues
• However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues
• Both CtBP1 and CtBP2 bind the δEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in δEF1
• CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF
• In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB
• Thus, CtBP1 and CtBP2 may be important corepressors for a variety of transcriptional factors
• Host Species: Mouse Clone: 3 Isotype: IgG1 Species Reactivity [for Features Main]: Mouse Immunogen: Mouse CtBP1 aa
• 345-441 Immunofluorescence, Western Blotting