CD42a Mouse anti-Human, BUV395, Clone: ALMA.16, BD Optibuild™

Description

• The ALMA.16 monoclonal antibody specifically recognizes CD42a
• CD42a is a 17-22 kDa type I transmembrane glycoprotein that is also known as Platelet glycoprotein IX (GPIX), or Glycoprotein 9 (GP9)
• CD42a forms a noncovalently linked complex (GPIb/GPIX/GPV) with CD42b, CD42c and CD42d that may serve as a receptor for von Willebrand factor
• It is expressed on platelets and megakaryocytes and is absent on the platelets of patients with Bernadr-Soulier Syndrome (BSS)
• Although the CD42a function is not fully understood, GPIX glycoprotein is important for the assembly and membrane expression of the CD42 complex and for the maintenance of the functional conformation of CD42b (GPIb)
• The antibody was conjugated to BD Horizon™ BUV395 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes
• This dye has been exclusively developed by BD Biosciences to have minimal spillover into other detectors, making it an optimal choice for multicolor flow cytometry
• With an Ex Max at 348 nm and an Em Max at 395 nm, BD Horizon BUV395 can be excited with a 355 nm laser and detected with a 379/28 filter
• BUV395 is a UV-excitable dye that has been developed exclusively by BD Biosciences
• With an excitation max of 348 nm and emission max of 395 nm, BUV395 can be excited by the 355nm laser and detected in a 379/28 filter
• This dye is optimal for multicolor flow cytometry because it has little to no spillover into other detectors.