CD51/CD61 Mouse anti-Human, Brilliant Violet 510, Clone: 23C6, BD Optibuild™

Description

• The 23C6 monoclonal antibody specifically binds to the Integrin αvβ3 heterodimeric complex (CD51/CD61) that is expressed on osteoclasts, endothelial cells,macrophages, melanoma cells, some B cells and in very low amounts on platelets
• This antibody has been reported to crossreact with chicken and rabbit, but not with rat αvβ3
• The integrin αvβ3heterodimer, often referred to as the vitronectin receptor, binds several ligands in addition to vitronectin including, von Willebrand factor, thrombospondin, osteopontin, bone sialoprotein, neural adhesion molecule L1, laminin, fibronectin, and fibrinogen
• The binding of some ligands to the vitronectin receptor has been reported to be inhibited by the 23C6 monoclonal antibody The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set
• BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser
• BV510 is a polymer-based dye that is brighter than BD Horizon V500
• Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.