CD61 Mouse Anti-Rat, Brilliant Violet 510, Clone: F11, BD Optibuild™

Description

• The F11 monoclonal antibody specifically recognizes integrin 3 chain (CD61), which associates with the integrin v chain (CD51), to form the vitronectin receptor found on endothelial cells, myeloid cells, and osteoclasts, and with the IIb chain (CD41) on platelets and megakaryocytes
• Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor
• The F11 antibody reportedly blocks the in vitro attachment of osteoclasts to several ligands
• Weak F11 antibody reactivity with human osteoclasts, megakaryocytes, and platelets has also been reported
• The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set
• BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser
• BV510 is a polymer-based dye that is brighter than BD Horizon V500
• Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.