CD161 Mouse anti-Human, Brilliant Violet 786, Clone: DX12, BD Optibuild™

Description

• The DX12 monoclonal antibody specifically binds to human CD161 which is also known as Natural killer cell surface protein P1A (NKR-P1A)
• CD161 is encoded by the KLRB1 /(Killer cell lectin-like receptor subfamily B member 1) gene
• CD161 is a member of the C-type lectin superfamily and is also referred to as C-type lectin domain family 5 member B (CLEC5B)
• CD161 is a 80 kDa disulfide-linked homodimer, type II membrane glycoprotein
• CD161 is expressed mostly on NK cell populations and on subsets of CD4+ and CD8+αβT cells, NKT cells andγδT cells
• Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells
• Its function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets
• The DX12 antibody can reportedly inhibit spontaneous cytotoxicity mediated by certain NK cell clones
• The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes
• This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm
• BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter)
• BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm
• BV786 offers a bright choice for the 6th detector off the violet laser.