CD89 Mouse anti-Human, BUV395, Clone: A59, BD Optibuild™

Description

• The A59 monoclonal antibody specifically recognizes CD89
• CD89 is the Fc receptor for IgA (Fc α R), a 55-75 kDa glycoprotein expressed exclusively on cells of granulocytic and monocyte/macrophage lineages in peripheral blood, but not on lymphocytes
• It is also expressed on promyelocytes in bone marrow and in the cytoplasm of fixed monocytes
• This mAb does not block IgA binding and is more efficient than native IgA ligands in the isolation of Fc α R molecules
• Fc α R plays a role in triggering phagocytosis and respiratory burst
• The antibody was conjugated to BD Horizon™ BUV395 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes
• This dye has been exclusively developed by BD Biosciences to have minimal spillover into other detectors, making it an optimal choice for multicolor flow cytometry
• With an Ex Max at 348 nm and an Em Max at 395 nm, BD Horizon BUV395 can be excited with a 355 nm laser and detected with a 379/28 filter
• BUV395 is a UV-excitable dye that has been developed exclusively by BD Biosciences
• With an excitation max of 348 nm and emission max of 395 nm, BUV395 can be excited by the 355nm laser and detected in a 379/28 filter
• This dye is optimal for multicolor flow cytometry because it has little to no spillover into other detectors.