CLIP Mouse, anti-Human, R718, Clone: CERCLIP, BD OptiBuild™

Description

• The CerCLIP monoclonal antibody specifically recognizes the class II associated invariant chain peptides (CLIP)
• CLIP is the remaining segment of class II invariant chain (Ii) after proteolytic degradation which stays associated with HLA-DR and represents a final intermediate in the removal of invariant chain from class II molecules during antigen processing
• The removal of CLIP and subsequent loading of the antigenic peptide is facilitated by the non-classical class II molecule HLA-DM
• CLIP can be detected, in association with HLA-DR, on the surface of T2DR3, a mutant cell line lacking HLA-DM.