CD307a (FCRL1) Mouse, anti-Human, R718, Clone: E3, BD OptiBuild™

Description

• The E3 monoclonal antibody specifically recognizes CD307a which is also known as Fc receptor-like protein 1 (FCRL1), Fc receptor homolog 1 (FCRH1), or Immune receptor translocation-associated protein 5 (IRTA5)
• CD307a (FCRL1) is a type I transmembrane glycoprotein that belongs to the IRTA gene family within the Ig gene superfamily
• It has three extracellular Ig-like domains, a glutamic acid residue in its transmembrane region, and two consensus immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic domain
• CD307a (FCRL1) bears sequence homology to classical Fc receptors
• CD307a (FCRL1) is first expressed on pre-B cells and increases with maturation being expressed on naïve and memory B cells
• It is downregulated by activated germinal center (GC) B cells
• It may also be expressed by B cell-derived leukemia and lymphoma cells
• CD307a may play key roles in B cell activation, differentiation and effector functions.