CP45100UL

MilliporeSigma™ anti-Clathrin Heavy Chain Clone: X22,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 CP45100UL-Each-of-1 In Stock ₹ 56,147.89

CP45100UL - Each of 1

₹ 56,147.89

In Stock

Quantity

1

Base Price: ₹ 56,147.89

GST (18%): ₹ 10,106.62

Total Price: ₹ 66,254.51

Antigen

Clathrin Heavy Chain

Classification

Monoclonal

Conjugate

Unconjugated

Host Species

Mouse

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Bovine, Human, Mouse, Rat

Form

Purified

Applications

Immunofluorescence, Immunoprecipitation

Clone

X22

Formulation

In PBS.

Immunogen

clathrin heavy chain purified from human brain

Regulatory Status

RUO

Test Specificity

Recognizes the ∽180kDa clathrin heavy chain protein.

Content And Storage

−20°C

Isotype

IgG1

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Description

  • Specifically detects Clathrin Heavy Chain Clone: X22 in Bovine, Human, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunoprecipitation At the unstimulated presynaptic nerve terminal, a pool of synaptic vesicles remains docked at active zones in preparation for exocytosis
  • Nerve terminal depolarization induced through an action potential stimulates the rise in intracellular Ca 2+ , which ultimately initiates the exocytotic process
  • Fused synaptic vesicles are rapidly replaced with vesicles from the reserve pool, while membranes of the fused vesicles are recaptured by endocytosis
  • Clathrin is one component involved in vesicle endocytosis, and is composed of three polypeptides, a ∽180kDa heavy chain and two ∽32-38kDa light chains which combine to create a distinct three-legged triskelion
  • It is this morphology that allows clathrin to form its unique polyhedral network
  • The clathrin-adaptor AP2 and the AP180/AP3 proteins also play a role in this process by forming a protein layer between the membrane and clathrin lattice
  • The interaction of the AP2 heterotetramer with synaptotagmin is believed to act as the template for recruitment of the AP3 and clathrin triskelia complex
  • Progression from clathrin-coated to free vesicles in the nerve terminus also requires dynamin.

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Antigen:
Clathrin Heavy Chain

Classification:
Monoclonal

Conjugate:
Unconjugated

Host Species:
Mouse

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Bovine, Human, Mouse, Rat

Form:
Purified

Applications:
Immunofluorescence, Immunoprecipitation

Clone:
X22

Formulation:
In PBS.

Immunogen:
clathrin heavy chain purified from human brain

Regulatory Status:
RUO

Test Specificity:
Recognizes the ∽180kDa clathrin heavy chain protein.

Content And Storage:
−20°C

Isotype:
IgG1

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Host Species:
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Primary or Secondary:
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Target Species:
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Form:
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Primary or Secondary:
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Immunogen:
recombinant human fibronectin

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