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FEMA549878

GRP78 Recombinant Rabbit Monoclonal Antibody (4H12), Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 FEMA549878-Each-of-1 In Stock ₹ 35,764.08

FEMA549878 - Each of 1

₹ 35,764.08

In Stock

Quantity

1

Base Price: ₹ 35,764.08

GST (18%): ₹ 6,437.534

Total Price: ₹ 42,201.614

Antigen

GRP78

Classification

Recombinant Monoclonal

Concentration

3 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.

P11021

Gene Symbols

Hspa5

Immunogen

A synthesized peptide derived from human GRP78 BiP

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Form

Liquid

Applications

ELISA, Immunohistochemistry (Paraffin)

Clone

4H12

Conjugate

Unconjugated

Gene

Hspa5

Gene Alias

78 kDa glucose-regulated protein, 78 kDa glucose-regulated protein homolog, 78-kD glucose-regulated protein precursor, AL022860, AU019543, baffled, Binding-immunoglobulin protein, bip, BiP protein, BiP/Grp78, cb865, D2Wsu141e, D2Wsu17e, Endoplasmic reticulum chaperone BiP, endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, epididymis secretory sperm binding protein Li 89n, fb60h09, fi36d04, FLJ26106, glucose regulated protein, 78 kDa, glucose-regulated protein, glucose-regulated protein, 78kDa, GRP 78, grp78, GRP-78, heat shock 70 kDa protein 5, heat shock 70 kDa protein 5a, heat shock 70kD protein 5, heat shock 70kD protein 5 (glucose-regulated protein, 78kD), heat shock 70kDa protein 5, heat shock 70kDa protein 5 (glucose-regulated protein), heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa), heat shock protein 5, heat shock protein 70 family protein 5, heat shock protein family A (Hsp70) member 5, heat shock protein family A (Hsp70) member 5 L homeolog, heat shock protein family A member 5, heavy-chain binding protein BiP, HEL-S-89n, Hsce70, hsp70, Hsp70 family ATPase KAR2, HSP70 family protein 5, HSPA 5, HSPA5, hspa5.L, hspa5a, I79_019946, immunoglobulin binding protein, immunoglobulin heavy chain-binding protein, Immunoglobulin heavy chain-binding protein homolog, J1248, KAR2, mBiP, MIF2, Sez7, SEZ-7, SSD1, Steroidogenesis-activator polypeptide, wu:fb60h09, wu:fi36d04, XAP-1, XAP-1 antigen, XELAEV_180384511mg, YJL034W, zgc:55994, zgc:77606

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

3309

Content And Storage

-20°C or -80°C if preferred

Isotype

IgG

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Description

  • Description GRP78 is a 78 kDa glucose regulated protein that belongs to the family of heat shock proteins that include HSP70
  • GRP78 is a resident protein of the endoplasmic reticulum (ER) and associates transiently with a variety of newly synthesized secretory and membrane proteins
  • GRP78 may also interact with mutant and misfolded proteins, marking them for degradation
  • The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C-terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP94) and protein disulfide isomerase (PDI)
  • The KDEL signal is recognized by the KDEL receptor and this interaction ensures recycling of escaped ER proteins back to the ER
  • GRP78’s involvement in correct folding of proteins and degradation of misfolded proteins is via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate
  • GRP78 is critical for maintenance of cell homeostasis and the prevention of apoptosis
  • GRP78 protein levels have been shown to be a reliable biomarker of hypoglycemia and serves a neuroprotective function in neurons exposed to glutamate and oxidative stress
  • GRP78 levels are reduced in the brains of Alzheimer's Disease patients, and decreased expression of GRP78 is found associated with missense mutations in the human presenilin-1 (PS1) gene
  • Further, the induction of the GRP78 protein has been associated with the development of drug-resistance to antitumor drugs.

Compare Similar Items

Show Difference

Img

Thermo Scientific

FEMA549878

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Antigen:
GRP78
Classification:
Recombinant Monoclonal
Concentration:
3 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.:
P11021
Gene Symbols:
Hspa5
Immunogen:
A synthesized peptide derived from human GRP78 BiP
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
ELISA, Immunohistochemistry (Paraffin)
Clone:
4H12
Conjugate:
Unconjugated
Gene:
Hspa5
Gene Alias:
78 kDa glucose-regulated protein, 78 kDa glucose-regulated protein homolog, 78-kD glucose-regulated protein precursor, AL022860, AU019543, baffled, Binding-immunoglobulin protein, bip, BiP protein, BiP/Grp78, cb865, D2Wsu141e, D2Wsu17e, Endoplasmic reticulum chaperone BiP, endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, epididymis secretory sperm binding protein Li 89n, fb60h09, fi36d04, FLJ26106, glucose regulated protein, 78 kDa, glucose-regulated protein, glucose-regulated protein, 78kDa, GRP 78, grp78, GRP-78, heat shock 70 kDa protein 5, heat shock 70 kDa protein 5a, heat shock 70kD protein 5, heat shock 70kD protein 5 (glucose-regulated protein, 78kD), heat shock 70kDa protein 5, heat shock 70kDa protein 5 (glucose-regulated protein), heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa), heat shock protein 5, heat shock protein 70 family protein 5, heat shock protein family A (Hsp70) member 5, heat shock protein family A (Hsp70) member 5 L homeolog, heat shock protein family A member 5, heavy-chain binding protein BiP, HEL-S-89n, Hsce70, hsp70, Hsp70 family ATPase KAR2, HSP70 family protein 5, HSPA 5, HSPA5, hspa5.L, hspa5a, I79_019946, immunoglobulin binding protein, immunoglobulin heavy chain-binding protein, Immunoglobulin heavy chain-binding protein homolog, J1248, KAR2, mBiP, MIF2, Sez7, SEZ-7, SSD1, Steroidogenesis-activator polypeptide, wu:fb60h09, wu:fi36d04, XAP-1, XAP-1 antigen, XELAEV_180384511mg, YJL034W, zgc:55994, zgc:77606
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3309
Content And Storage:
-20°C or -80°C if preferred
Isotype:
IgG

Img

Thermo Scientific

FEMA549879

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Antigen:
ADAM17
Classification:
Recombinant Monoclonal
Concentration:
1.6 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.:
P78536
Gene Symbols:
ADAM17
Immunogen:
A synthesized peptide derived from human ADAM17
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
ELISA, Immunocytochemistry
Clone:
5A1
Conjugate:
Unconjugated
Gene:
ADAM17
Gene Alias:
a disintegrin and metallopeptidase domain 17, a disintegrin and metalloprotease domain 17, a disintegrin and metalloproteinase, a disintegrin and metalloproteinase domain 17, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), ADAM, ADAM 17, ADAM metallopeptidase domain 17, ADAM metallopeptidase domain 18, Adam17, ADAM18, ADAMs, CD156B, CD156b antigen, CSVP, Disintegrin and metalloproteinase domain-containing protein 17, metalloendopeptidases, NISBD, NISBD1, Snake venom-like protease, TACE, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, tumor necrosis factor, alpha, converting enzyme
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6868
Content And Storage:
-20°C or -80°C if preferred
Isotype:
IgG

Img

Thermo Scientific

FEMA549883

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Antigen:
PAK2
Classification:
Recombinant Monoclonal
Concentration:
0.53 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.:
Q13177, Q64303, Q8CIN4
Gene Symbols:
Pak2
Immunogen:
A synthesized peptide derived from human PAK2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
ELISA, Flow Cytometry, Immunoprecipitation, Western Blot
Clone:
6D12
Conjugate:
Unconjugated
Gene:
Pak2
Gene Alias:
5330420P17Rik, A130002K10Rik, AI836325, Alpha-PAK, Beta-PAK, C-t-PAK2, D16Ertd269e, gamma pak, gamma-PAK, mKIAA4182, Oligophrenin-3, OPHN3, p21 (CDKN1A)-activated kinase 2, p21 (RAC1) activated kinase 2, p21 protein (Cdc42/Rac)-activated kinase 2, p21-activated kinase 2, p27, p34, p58, p65-PAK, PAK alpha, PAK beta, PAK gamma, PAK1, PAK-1, Pak2, PAK-2, PAK-2p27, PAK-2p34, PAK3, PAK-3, PAK65, PAKgamma, S6/H4 kinase, serine/threonine-protein kinase PAK 2
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
224105, 29432, 5062
Content And Storage:
-20°C or -80°C if preferred
Isotype:
IgG

Img

Thermo Scientific

FEMA549884

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Antigen:
Huntingtin
Classification:
Recombinant Monoclonal
Concentration:
0.63 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.:
P42858
Gene Symbols:
Htt
Immunogen:
A synthesized peptide derived from human Huntingtin
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
ELISA, Immunohistochemistry (Paraffin)
Clone:
6F2
Conjugate:
Unconjugated
Gene:
Htt
Gene Alias:
AI256365, C430023I11Rik, Hd, HD protein, HD protein homolog, Hdh, HTT, Huntingtin, huntingtin (Huntington disease), Huntingtin, myristoylated N-terminal fragment, Huntington disease gene homolog, huntington disease protein, huntington disease protein homolog, IT15, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3064
Content And Storage:
-20°C or -80°C if preferred
Isotype:
IgG