FEMA550750
SMAD4 Recombinant Rabbit Monoclonal Antibody (PD01-37), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550750-Each-of-1 | In Stock | ₹ 40,641.00 |
FEMA550750 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,641.00
GST (18%): ₹ 7,315.38
Total Price: ₹ 47,956.38
Antigen
SMAD4
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
O70437, P97471, Q13485
Gene Symbols
SMAD4
Immunogen
Synthetic peptide within Human Smad4 aa 500-552/552 (C terminal).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
PD01-37
Conjugate
Unconjugated
Gene
SMAD4
Gene Alias
AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17128, 4089, 50554
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Positive control: PC-12 cell lysate, SH-SY5Y cell lysate, human lung carcinoma tissue, human testis tissue, human stomach carcinoma tissue, PANC-1
- Predicted band size: 60 kDa Subcellular Location: Cytoplasm, Nucleus
- Smad4 is encoded by the Smad4 gene that is located on chromosome 18 in humans
- Smad4 is also known as Smad family member 4, Sma- and Mad-related protein 4 or Mothers against decapentaplegic (MAD) homolog 4
- Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) globular domains that are involved in DNA binding and protein interactions respectively
- Binding of the TGF-beta superfamily of ligands that includes Transforming Growth Factor -beta (TGF-beta) and bone morphogenetic protein (BMP) to its cognate receptor allows phosphorylation of Smad 1, 2, 3, 5 and 8 (R-Smad, Receptor Smad)
- This signals for heterotrimerization with Smad4 (co-Smad, co-mediator Smad) and translocation of the complex to the nucleus
- Inhibitory or antagonistic Smad (I-Smad) that includes Smad 6 and 7, interact with activated R-Smads and attenuate the signaling pathway
- Smad4 acts as a tumor suppressor protein by transcriptionally regulating its target genes such as Cyclin D1 (downregulation) and collagen (upregulation) that inhibit cell proliferation
- Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.
Compare Similar Items
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Antigen: SMAD4
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.: O70437, P97471, Q13485
Gene Symbols: SMAD4
Immunogen: Synthetic peptide within Human Smad4 aa 500-552/552 (C terminal).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: PD01-37
Conjugate: Unconjugated
Gene: SMAD4
Gene Alias: AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 17128, 4089, 50554
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Antigen:
SMAD4
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.:
O70437, P97471, Q13485
Gene Symbols:
SMAD4
Immunogen:
Synthetic peptide within Human Smad4 aa 500-552/552 (C terminal).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
PD01-37
Conjugate:
Unconjugated
Gene:
SMAD4
Gene Alias:
AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
17128, 4089, 50554
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG
Antigen: AFP
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.: P02771
Gene Symbols: AFP
Immunogen: Recombinant full length protein corresponding to Human alpha 1 Fetoprotein aa 1-609/609.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Clone: PD00-71
Conjugate: Unconjugated
Gene: AFP
Gene Alias: a fetoglobulin, a fetoprotein, Afp, AFPD, Alpha fetoglobulin, alpha fetoprotein, alpha-1-fetoprotein, Alpha-fetoglobulin, alpha-fetoprotein, alpha-fetoprotein precursor, alpha-foetoprotein, chloride intracellular channel 6, FETA, fetoglobulin, fetoprotein, HPAFP, a fetoglobulin, a fetoprotein
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 174
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Antigen:
AFP
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.:
P02771
Gene Symbols:
AFP
Immunogen:
Recombinant full length protein corresponding to Human alpha 1 Fetoprotein aa 1-609/609.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Clone:
PD00-71
Conjugate:
Unconjugated
Gene:
AFP
Gene Alias:
a fetoglobulin, a fetoprotein, Afp, AFPD, Alpha fetoglobulin, alpha fetoprotein, alpha-1-fetoprotein, Alpha-fetoglobulin, alpha-fetoprotein, alpha-fetoprotein precursor, alpha-foetoprotein, chloride intracellular channel 6, FETA, fetoglobulin, fetoprotein, HPAFP, a fetoglobulin, a fetoprotein
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
174
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG
Antigen: SOX10
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.: O55170, P56693, Q04888
Gene Symbols: SOX10
Immunogen: Synthetic peptide within C terminal human SOX10 aa 457-466/466.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: PDH0-05
Conjugate: Unconjugated
Gene: SOX10
Gene Alias: cls, cls/sox10, colorless, colourless, colourless/sox10, DOM, dominant megacolon, dominant megacolon, mouse, human homolog of, golas, gos, HMG-box transcription factor Sox10, MGC15649, PCWH, Protein SOX-21, SOX10, Sox-10, sox10 protein, sox10b, Sox21, SOX9, SRY, SRY (sex determining region Y)-box 10, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal), SRY box 10, SRY-box 10, SRY-box containing gene 10, SRY-box containing protein 10, SRY-box transcription factor 10, SRY-related HMG-box gene 10, transcription factor SOX-10, Transcription factor SOX-M, WS2E, WS4, WS4C, zgc:100757
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 20665, 29361, 6663
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Antigen:
SOX10
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.:
O55170, P56693, Q04888
Gene Symbols:
SOX10
Immunogen:
Synthetic peptide within C terminal human SOX10 aa 457-466/466.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
PDH0-05
Conjugate:
Unconjugated
Gene:
SOX10
Gene Alias:
cls, cls/sox10, colorless, colourless, colourless/sox10, DOM, dominant megacolon, dominant megacolon, mouse, human homolog of, golas, gos, HMG-box transcription factor Sox10, MGC15649, PCWH, Protein SOX-21, SOX10, Sox-10, sox10 protein, sox10b, Sox21, SOX9, SRY, SRY (sex determining region Y)-box 10, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal), SRY box 10, SRY-box 10, SRY-box containing gene 10, SRY-box containing protein 10, SRY-box transcription factor 10, SRY-related HMG-box gene 10, transcription factor SOX-10, Transcription factor SOX-M, WS2E, WS4, WS4C, zgc:100757
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
20665, 29361, 6663
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG
Antigen: SOX10
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.: O55170, P56693, Q04888
Gene Symbols: SOX10
Immunogen: Synthetic peptide within C terminal human SOX10 aa 457-466/466.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: PDH0-04
Conjugate: Unconjugated
Gene: SOX10
Gene Alias: cls, cls/sox10, colorless, colourless, colourless/sox10, DOM, dominant megacolon, dominant megacolon, mouse, human homolog of, golas, gos, HMG-box transcription factor Sox10, MGC15649, PCWH, Protein SOX-21, SOX10, Sox-10, sox10 protein, sox10b, Sox21, SOX9, SRY, SRY (sex determining region Y)-box 10, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal), SRY box 10, SRY-box 10, SRY-box containing gene 10, SRY-box containing protein 10, SRY-box transcription factor 10, SRY-related HMG-box gene 10, transcription factor SOX-10, Transcription factor SOX-M, WS2E, WS4, WS4C, zgc:100757
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 20665, 29361, 6663
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Antigen:
SOX10
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.:
O55170, P56693, Q04888
Gene Symbols:
SOX10
Immunogen:
Synthetic peptide within C terminal human SOX10 aa 457-466/466.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
PDH0-04
Conjugate:
Unconjugated
Gene:
SOX10
Gene Alias:
cls, cls/sox10, colorless, colourless, colourless/sox10, DOM, dominant megacolon, dominant megacolon, mouse, human homolog of, golas, gos, HMG-box transcription factor Sox10, MGC15649, PCWH, Protein SOX-21, SOX10, Sox-10, sox10 protein, sox10b, Sox21, SOX9, SRY, SRY (sex determining region Y)-box 10, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal), SRY box 10, SRY-box 10, SRY-box containing gene 10, SRY-box containing protein 10, SRY-box transcription factor 10, SRY-related HMG-box gene 10, transcription factor SOX-10, Transcription factor SOX-M, WS2E, WS4, WS4C, zgc:100757
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
20665, 29361, 6663
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG