MABS200025
LXR alpha, Mouse anti-Mouse, Rat, Clone: 2B7, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS200025-Each-of-1 | In Stock | ₹ 15,999.72 |
MABS200025 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,999.72
GST (18%): ₹ 2,879.95
Total Price: ₹ 18,879.67
Antigen
LXR alpha
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
Nr1h3;Lxra
Immunogen
GST-tagged full length recombinant rat LXR-alpha protein.
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
Clone 2B7 detects LXR-alpha in mouse and rat liver tissue.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1
Applications
Immunoprecipitation, Western Blot
Clone
2B7
Dilution
Immunoprecipitation Analysis: A representative lot detected LXR alpha in Immunoprecipitation applications (Tian, J., et. al. (2016). Proc Natl Acad Sci USA. 113(29):8182-7).Western Blotting Analysis: A representative lot detected LXR alpha in Western Blotting applications (Tian, J., et. al. (2016). Proc Natl Acad Sci USA. 113(29):8182-7).
Gene Alias
Oxysterols receptor LXR-alpha;Liver X receptor alpha;Nuclear receptor subfamily 1 group H member 3;RLD-1
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse, Rat
Form
Purified
Related Products
Description
- Anti-LXR alpha, clone 2B7, Cat
- No
- MABS2000, is a mouse monocloanl antibody that detects Oxysterols receptor LXR-alpha and has been tested for use in Immunoprecipitation and Western Blotting
- Oxysterols receptor LXR-alpha (UniProt: Q62685; also known as Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, RLD-1) is encoded by the Nr1h3 (also known as Lxra) gene in rat
- Liver X receptors (LXRs) are members of the nuclear receptor superfamily that have been implicated in lipid homeostasis and glucose metabolism
- Oxysterols, oxidized derivatives of cholesterol, are ligands for LXRs
- LXRs act as cholesterol sensors; when cellular oxysterols accumulate as a result of increasing concentrations of cholesterol, LXR induces the transcription of genes that protect cells from cholesterol overload
- LXRs bind to consensus elements (LXR response elements, LXREs) as heterodimers with isoforms of the retinoid X receptor (RXR)
- LXR-alpha is an important regulator of cholesterol and bile acid metabolism
- It interacts with RXR and shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES
- In adults it is expressed in spleen, pituitary, lung, liver, and fat and a weaker expression is observed in several other tissues
- LXR-alpha contains a transactivation domain (AF-1; aa 1-94) that is required for ligand-independent transactivation function; another transactivation domain (AF-2; aa 203-445) that is required for ligand-dependent transactivation function; and a ligand binding domain (aa 213-432)
- (Ref.: Zhao, C., and Dahlman-Wright, K
- (2010)
- J
- Endocrinol
- 204, 233-240).
Compare Similar Items
Show Difference
Antigen: LXR alpha
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: Nr1h3;Lxra
Immunogen: GST-tagged full length recombinant rat LXR-alpha protein.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 2B7 detects LXR-alpha in mouse and rat liver tissue.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Applications: Immunoprecipitation, Western Blot
Clone: 2B7
Dilution: Immunoprecipitation Analysis: A representative lot detected LXR alpha in Immunoprecipitation applications (Tian, J., et. al. (2016). Proc Natl Acad Sci USA. 113(29):8182-7).Western Blotting Analysis: A representative lot detected LXR alpha in Western Blotting applications (Tian, J., et. al. (2016). Proc Natl Acad Sci USA. 113(29):8182-7).
Gene Alias: Oxysterols receptor LXR-alpha;Liver X receptor alpha;Nuclear receptor subfamily 1 group H member 3;RLD-1
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Mouse, Rat
Form: Purified
Antigen:
LXR alpha
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
Nr1h3;Lxra
Immunogen:
GST-tagged full length recombinant rat LXR-alpha protein.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 2B7 detects LXR-alpha in mouse and rat liver tissue.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Applications:
Immunoprecipitation, Western Blot
Clone:
2B7
Dilution:
Immunoprecipitation Analysis: A representative lot detected LXR alpha in Immunoprecipitation applications (Tian, J., et. al. (2016). Proc Natl Acad Sci USA. 113(29):8182-7).Western Blotting Analysis: A representative lot detected LXR alpha in Western Blotting applications (Tian, J., et. al. (2016). Proc Natl Acad Sci USA. 113(29):8182-7).
Gene Alias:
Oxysterols receptor LXR-alpha;Liver X receptor alpha;Nuclear receptor subfamily 1 group H member 3;RLD-1
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Form:
Purified
Antigen: mPEG
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2b in PBS with 0.04% sodium azide.
Gene Symbols: __
Immunogen: Methoxy PEG covalently conjugated to E.coli beta-glucuronidase.
Quantity: 100 μg
Research Discipline: Signaling
Test Specificity: Clone 15-2b specifically detects proteins conjugated with methoxy polyethylene glycol (mPEG).
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2b κ
Applications: ELISA
Clone: 15-2b
Dilution: __
Gene Alias: Methoxy polyethylene glycol
Host Species: Mouse
Purification Method: Protein A purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: All species
Form: Purified
Antigen:
mPEG
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2b in PBS with 0.04% sodium azide.
Gene Symbols:
__
Immunogen:
Methoxy PEG covalently conjugated to E.coli beta-glucuronidase.
Quantity:
100 μg
Research Discipline:
Signaling
Test Specificity:
Clone 15-2b specifically detects proteins conjugated with methoxy polyethylene glycol (mPEG).
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2b κ
Applications:
ELISA
Clone:
15-2b
Dilution:
__
Gene Alias:
Methoxy polyethylene glycol
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
All species
Form:
Purified
Antigen: mPEG
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2b in PBS with 0.04% sodium azide.
Gene Symbols: __
Immunogen: Methoxy PEG covalently conjugated to E.coli beta-glucuronidase.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 15-2b specifically detects proteins conjugated with methoxy polyethylene glycol (mPEG).
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2b κ
Applications: ELISA
Clone: 15-2b
Dilution: __
Gene Alias: Methoxy polyethylene glycol
Host Species: Mouse
Purification Method: Protein A purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: All species
Form: Purified
Antigen:
mPEG
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2b in PBS with 0.04% sodium azide.
Gene Symbols:
__
Immunogen:
Methoxy PEG covalently conjugated to E.coli beta-glucuronidase.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 15-2b specifically detects proteins conjugated with methoxy polyethylene glycol (mPEG).
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2b κ
Applications:
ELISA
Clone:
15-2b
Dilution:
__
Gene Alias:
Methoxy polyethylene glycol
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
All species
Form:
Purified
Antigen: EphA2
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: EPHA2;ECK
Immunogen: KP-2, KP-3, SUIT-2, and MIAPaCa-2 cells.
Quantity: 100 μg
Research Discipline: Signaling
Test Specificity: Clone F2-27 specifically detects Ephrin type -A receptor 2 in human.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Flow Cytometry, Immunoprecipitation, Inhibition Assays
Clone: F2-27
Dilution: Inhibition Analysis: A representative lot inhibited cancer cell invasion in a three-dimensional spheroid formation assay. (Tanaka, T., et. al. (2017). Transl Oncol. 10(4):476-484).Immunoprecipitation Analysis: A representative lot detected EphA2 in Immunoprecipitation applications (Tanaka, T., et. al. (2017). Transl Oncol. 10(4):476-484).Flow Cytometry Analysis: A representative lot detected EphA2 in Flow Cytometry applications (Tanaka, T., et. al. (2017). Transl Oncol. 10(4):476-484).
Gene Alias: Ephrin type-A receptor 2;EC: 2.7.10.1;Epithelial cell kinase;Tyrosine-protein kinase receptor ECK
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
EphA2
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
EPHA2;ECK
Immunogen:
KP-2, KP-3, SUIT-2, and MIAPaCa-2 cells.
Quantity:
100 μg
Research Discipline:
Signaling
Test Specificity:
Clone F2-27 specifically detects Ephrin type -A receptor 2 in human.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Immunoprecipitation, Inhibition Assays
Clone:
F2-27
Dilution:
Inhibition Analysis: A representative lot inhibited cancer cell invasion in a three-dimensional spheroid formation assay. (Tanaka, T., et. al. (2017). Transl Oncol. 10(4):476-484).Immunoprecipitation Analysis: A representative lot detected EphA2 in Immunoprecipitation applications (Tanaka, T., et. al. (2017). Transl Oncol. 10(4):476-484).Flow Cytometry Analysis: A representative lot detected EphA2 in Flow Cytometry applications (Tanaka, T., et. al. (2017). Transl Oncol. 10(4):476-484).
Gene Alias:
Ephrin type-A receptor 2;EC: 2.7.10.1;Epithelial cell kinase;Tyrosine-protein kinase receptor ECK
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified