MABT134125
Lamin A/C, Mouse anti-Monkey, Syrian Hamster, Rat, Mouse, Human, Clone: 4C11, Millipore Sigma™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT134125-Each-of-1 | In Stock | ₹ 16,456.61 |
MABT134125 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Lamin A/C
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
LMNA;LMN1
Immunogen
Purified protein corresponding to the Ig-fold of human Lamin A/C.
Quantity
25 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_001244303
Target Species
Monkey, Syrian Hamster, Rat, Mouse, Human
Form
Purified
Applications
ChIP Assay, Immunofluorescence, Immunoprecipitation, Western Blot
Clone
4C11
Dilution
Western Blotting Analysis: A representative lot detected Lamin A/C in Western Blotting applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73; Roblek, M., et. al. (2010). PLoS One. 5(5):e10604).Dot Blot Analysis: A representative lot detected Lamin A/C in Dot Blot applications (Roblek, M., et. al. (2010). PLoS One. 5(5):e10604). Immunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected Lamin A/C in HeLa cells.Western Blotting Analysis: A representative lot detected Lamin A/C in WB used to demonstrate high titration and excellent properties of clone 4C11 (Courtesy of Marie lang, M.D., Stefan Schuchner, Ph.D. and Egon Ogris, M.D., Medical University of Vienna, Austria).Immunofluorescence Analysis: A representative lot detected the Lamin A/C species at the nuclear lamina of HeLa cells (Courtesy of Marie Lang, M.D., Stefan Schuchner, Ph.D. and Egon Ogris, M.D., Medical University of Vienna, Austria).Immunoprecipitation Analysis: A representative lot de
Gene Alias
70 kDa Lamin;Renal carcinoma antigen NY-REN-32
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 4C11 detects Lamin A/C at the nuclear lamina in multiple species.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Anti-Lamin A/C, clone 4C11, Cat
- No
- MABT1341, is a highly specific mouse monoclonal antibody that targets Lamin A/C and has been tested for use in Immunofluorescence, Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), and Western Blotting
- Prelamin-A/C (UniProt: P02545) is encoded by the LMNA (also known as LMN1) gene (Gene ID: 4000) in human
- It is cleaved into Lamin-A/C (also known as 70 kDa Lamin, Renal carcinoma antigen NY-REN-32)
- Lamins are components of the nuclear lamina that provide a framework for the nuclear envelope and may also interact with chromatin
- Lamin A and C are present in equal amounts in the lamina of mammals
- Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics
- Lamin A is initially synthesized as prelamin A that undergoes several modifications in the carboxyl terminal region that allow incorporation of prelamin A into the nuclear envelope and its subsequent processing into the mature lamin A
- Cleavage of 15 residues (aa 647-662) by ZMPSTE24/FACE1 generates the final protein product
- Unlike mature lamin A, prelamin A accumulates as discrete and localized foci at the nuclear periphery
- Prelamin-A/C can accelerate smooth muscle cell senescence
- It can act to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence
- Mutations in LMNA gene are known to cause Emery-Dreifuss muscular dystrophy that is characterized by weakness and atrophy of muscle without involvement of the nervous system
- Some mutations have also been linked to familial type of lipodystrophy characterized by the loss of subcutaneous adipose tissue in the lower parts of the body
- (Ref.: Casasola, A., et al
- (2016)
- Nucleus 7(1); 84-102).
Compare Similar Items
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Antigen: Lamin A/C
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: LMNA;LMN1
Immunogen: Purified protein corresponding to the Ig-fold of human Lamin A/C.
Quantity: 25 μg
Research Discipline: Cell Structure
Gene ID (Entrez): NP_001244303
Target Species: Monkey, Syrian Hamster, Rat, Mouse, Human
Form: Purified
Applications: ChIP Assay, Immunofluorescence, Immunoprecipitation, Western Blot
Clone: 4C11
Dilution: Western Blotting Analysis: A representative lot detected Lamin A/C in Western Blotting applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73; Roblek, M., et. al. (2010). PLoS One. 5(5):e10604).Dot Blot Analysis: A representative lot detected Lamin A/C in Dot Blot applications (Roblek, M., et. al. (2010). PLoS One. 5(5):e10604). Immunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected Lamin A/C in HeLa cells.Western Blotting Analysis: A representative lot detected Lamin A/C in WB used to demonstrate high titration and excellent properties of clone 4C11 (Courtesy of Marie lang, M.D., Stefan Schuchner, Ph.D. and Egon Ogris, M.D., Medical University of Vienna, Austria).Immunofluorescence Analysis: A representative lot detected the Lamin A/C species at the nuclear lamina of HeLa cells (Courtesy of Marie Lang, M.D., Stefan Schuchner, Ph.D. and Egon Ogris, M.D., Medical University of Vienna, Austria).Immunoprecipitation Analysis: A representative lot de
Gene Alias: 70 kDa Lamin;Renal carcinoma antigen NY-REN-32
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 4C11 detects Lamin A/C at the nuclear lamina in multiple species.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Lamin A/C
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
LMNA;LMN1
Immunogen:
Purified protein corresponding to the Ig-fold of human Lamin A/C.
Quantity:
25 μg
Research Discipline:
Cell Structure
Gene ID (Entrez):
NP_001244303
Target Species:
Monkey, Syrian Hamster, Rat, Mouse, Human
Form:
Purified
Applications:
ChIP Assay, Immunofluorescence, Immunoprecipitation, Western Blot
Clone:
4C11
Dilution:
Western Blotting Analysis: A representative lot detected Lamin A/C in Western Blotting applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73; Roblek, M., et. al. (2010). PLoS One. 5(5):e10604).Dot Blot Analysis: A representative lot detected Lamin A/C in Dot Blot applications (Roblek, M., et. al. (2010). PLoS One. 5(5):e10604). Immunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected Lamin A/C in HeLa cells.Western Blotting Analysis: A representative lot detected Lamin A/C in WB used to demonstrate high titration and excellent properties of clone 4C11 (Courtesy of Marie lang, M.D., Stefan Schuchner, Ph.D. and Egon Ogris, M.D., Medical University of Vienna, Austria).Immunofluorescence Analysis: A representative lot detected the Lamin A/C species at the nuclear lamina of HeLa cells (Courtesy of Marie Lang, M.D., Stefan Schuchner, Ph.D. and Egon Ogris, M.D., Medical University of Vienna, Austria).Immunoprecipitation Analysis: A representative lot de
Gene Alias:
70 kDa Lamin;Renal carcinoma antigen NY-REN-32
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 4C11 detects Lamin A/C at the nuclear lamina in multiple species.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: VE-cadherin
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: CDH5, CD144, 7B4
Immunogen: HUVEC cells
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: BV6
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG2a κ
Antigen:
VE-cadherin
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
CDH5, CD144, 7B4
Immunogen:
HUVEC cells
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
BV6
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for one year
Isotype:
IgG2a κ
Antigen: C-Nap1 (Cep250)
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: CEP250;CEP2;CNAP1
Immunogen: Recombinant fragment corresponding to 455 amino acids from the C-terminal region of human Centrosome-associated protein CEP250.
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_001305148
Target Species: Human
Form: Purified
Applications: Immunofluorescence, Western Blot
Clone: 150-230-1
Dilution: Immunofluorescence Analysis: A representative lot detected C-Nap1 (Cep250) in Immunofluorescence applications (Fava, L.L., et. al. (2017). Genes Dev. 31(1):34-45).Western Blotting Analysis: A representative lot detected C-Nap1 (Cep250) in HeLa S3 cell lysates. (Courtesy of Prof. Erich A. Nigg, Ph.D., Biozentrum, University of Basel, Switzerland).
Gene Alias: Centrosome-associated protein CEP250;250 kDa centrosomal protein;Cep250;Centrosomal Nek2-associated protein 1;C-Nap1;Centrosomal protein 2
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 150-230-1 is a mouse monoclonal antibody that detects human Centrosome-associated protein CEP250 (Cep20). It targets an epitope within 455 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
C-Nap1 (Cep250)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
CEP250;CEP2;CNAP1
Immunogen:
Recombinant fragment corresponding to 455 amino acids from the C-terminal region of human Centrosome-associated protein CEP250.
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_001305148
Target Species:
Human
Form:
Purified
Applications:
Immunofluorescence, Western Blot
Clone:
150-230-1
Dilution:
Immunofluorescence Analysis: A representative lot detected C-Nap1 (Cep250) in Immunofluorescence applications (Fava, L.L., et. al. (2017). Genes Dev. 31(1):34-45).Western Blotting Analysis: A representative lot detected C-Nap1 (Cep250) in HeLa S3 cell lysates. (Courtesy of Prof. Erich A. Nigg, Ph.D., Biozentrum, University of Basel, Switzerland).
Gene Alias:
Centrosome-associated protein CEP250;250 kDa centrosomal protein;Cep250;Centrosomal Nek2-associated protein 1;C-Nap1;Centrosomal protein 2
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 150-230-1 is a mouse monoclonal antibody that detects human Centrosome-associated protein CEP250 (Cep20). It targets an epitope within 455 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: GM130
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: Golga2
Immunogen: A full length recombinant human Golgin subfamily A member 2 (GM130).
Quantity: 25 μL
Research Discipline: Cell Structure
Gene ID (Entrez): __
Target Species: Rat, Human
Form: Purified
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 4A3
Dilution: Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected GM130 in human liver cancer tissue.Western Blotting Analysis: A representative lot detected GM130 in Western Blotting applications (Diao, A., et. al. (2003) J Cell Biol. 160(2):201-12).Immunocytochemistry Analysis: A representative lot detected GM130 in Immunocytochemistry applications (Seemann, J., et. al. (2002). Science. 295(5556):848-51; Diao, A., et. al. (2003) J Cell Biol. 160(2):201-12).Immunohistochemistry Analysis: A representative lot detected GM130 in Immunohistochemistry applications (Seemann, J., et. al. (2002). Science. 295(5556):848-51).Immunoprecipitation Analysis: A representative lot detected GM130 in Immunoprecipitation applications (Diao, A., et. al. (2003) J Cell Biol. 160(2):201-12; Diao, A., et. al. (2008) J Cell Biol. 283(11):6957-67).
Gene Alias: Golgin subfamily A member 2;130 kDa cis-Golgi matrix protein
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 4A3 detected Golgin subfamily A member 2 (GM130) in human liver cancer and human intestine sections.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
GM130
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
Golga2
Immunogen:
A full length recombinant human Golgin subfamily A member 2 (GM130).
Quantity:
25 μL
Research Discipline:
Cell Structure
Gene ID (Entrez):
__
Target Species:
Rat, Human
Form:
Purified
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
4A3
Dilution:
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected GM130 in human liver cancer tissue.Western Blotting Analysis: A representative lot detected GM130 in Western Blotting applications (Diao, A., et. al. (2003) J Cell Biol. 160(2):201-12).Immunocytochemistry Analysis: A representative lot detected GM130 in Immunocytochemistry applications (Seemann, J., et. al. (2002). Science. 295(5556):848-51; Diao, A., et. al. (2003) J Cell Biol. 160(2):201-12).Immunohistochemistry Analysis: A representative lot detected GM130 in Immunohistochemistry applications (Seemann, J., et. al. (2002). Science. 295(5556):848-51).Immunoprecipitation Analysis: A representative lot detected GM130 in Immunoprecipitation applications (Diao, A., et. al. (2003) J Cell Biol. 160(2):201-12; Diao, A., et. al. (2008) J Cell Biol. 283(11):6957-67).
Gene Alias:
Golgin subfamily A member 2;130 kDa cis-Golgi matrix protein
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 4A3 detected Golgin subfamily A member 2 (GM130) in human liver cancer and human intestine sections.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2b κ