CD46 Antibody (122.2), Novus Biologicals™
Manufacturer: Fischer Scientific
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Antigen
CD46
Classification
Monoclonal
Concentration
0.2mg/mL
Dilution
Flow Cytometry 0.5-1ug/million cells in 0.1ml, SDS-Page, Immunofluorescence 0.5-1ug/ml
Gene Accession No.
NP_002380
Gene Symbols
CD46
Immunogen
A recombinant protein fragment specific for human CD46 was used as the immunogen.
Quantity
0.2 mg
Research Discipline
Cancer, Cell Biology, Cellular Markers, Immunology
Gene ID (Entrez)
4179
Target Species
Human
Form
Purified
Applications
Flow Cytometry, SDS-Page, Immunofluorescence
Clone
122.2
Conjugate
Unconjugated
Formulation
PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Alias
AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Content And Storage
Store at 4C.
Isotype
IgG1 κ
Related Products
Description
- CD46 Monoclonal specifically detects CD46 in Human samples
- It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Functional, Immunofluorescence.
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Antigen: CD46
Classification: Monoclonal
Concentration: 0.2mg/mL
Dilution: Flow Cytometry 0.5-1ug/million cells in 0.1ml, SDS-Page, Immunofluorescence 0.5-1ug/ml
Gene Accession No.: NP_002380
Gene Symbols: CD46
Immunogen: A recombinant protein fragment specific for human CD46 was used as the immunogen.
Quantity: 0.2 mg
Research Discipline: Cancer, Cell Biology, Cellular Markers, Immunology
Gene ID (Entrez): 4179
Target Species: Human
Form: Purified
Applications: Flow Cytometry, SDS-Page, Immunofluorescence
Clone: 122.2
Conjugate: Unconjugated
Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Alias: AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Antigen: CCR6
Classification: Monoclonal
Concentration: __
Dilution: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Accession No.: __
Gene Symbols: CCR6
Immunogen: A recombinant protein consisting of the external domains of mouse CD196 (CCR6) was used as the immunogen for the antibody.
Quantity: 0.1 mL
Research Discipline: Cytokine Research, GPCR, Immunology, Innate Immunity, Signal Transduction
Gene ID (Entrez): 1235
Target Species: Human, Mouse
Form: Purified
Applications: Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone: 18B9E6
Conjugate: Biotin
Formulation: __
Gene Alias: BN-1, CC-CKR-6, CCR-6, CD196 antigen, chemokine (C-C motif) receptor 6, CKR-L3G-protein coupled receptor 29, CKRL3LARC receptor, CMKBR6STRL22, DRY6, GPR29C-C CKR-6, GPRCY4DRY-6, lymphocyte, 22
Host Species: Rat
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This product reacts with Mouse.
Content And Storage: Store at 4C in the dark.
Isotype: IgG2a κ
Antigen: CCR6
Classification: Monoclonal
Concentration: __
Dilution: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Accession No.: __
Gene Symbols: CCR6
Immunogen: A recombinant protein consisting of the external domains of mouse CD196 (CCR6) was used as the immunogen for the antibody.
Quantity: 0.1 mL
Research Discipline: Cytokine Research, GPCR, Immunology, Innate Immunity, Signal Transduction
Gene ID (Entrez): 1235
Target Species: Human, Mouse
Form: Purified
Applications: Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone: 18B9E6
Conjugate: DyLight 488
Formulation: __
Gene Alias: BN-1, CC-CKR-6, CCR-6, CD196 antigen, chemokine (C-C motif) receptor 6, CKR-L3G-protein coupled receptor 29, CKRL3LARC receptor, CMKBR6STRL22, DRY6, GPR29C-C CKR-6, GPRCY4DRY-6, lymphocyte, 22
Host Species: Rat
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This product reacts with Mouse.
Content And Storage: Store at 4C in the dark.
Isotype: IgG2a κ