NBP229451
Thyroglobulin Antibody (2H11), Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP229451-Each-of-1 | In Stock | ₹ 44,833.44 |
NBP229451 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,833.44
GST (18%): ₹ 8,070.019
Total Price: ₹ 52,903.459
Antigen
Thyroglobulin
Classification
Monoclonal
Concentration
0.2 mg/ml
Dilution
Flow Cytometry 0.5-1ug/million cells in 0.1ml, Immunohistochemistry-Paraffin 0.1-0.2ug/ml
Gene Alias
AITD3TGN, TDH3, Tg, thyroglobulin
Host Species
Mouse
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
monoclonal antibody 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by monoclonal antibody 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-th
Content And Storage
Store at 4C.
Isotype
IgG1 κ
Applications
Flow Cytometry, Immunohistochemistry (Paraffin)
Clone
2H11
Conjugate
Unconjugated
Gene Accession No.
P01266
Gene Symbols
TG
Immunogen
Human thyroid follicular cells were used as immunogen to generate the antibody.
Quantity
0.1 mg
Research Discipline
Cancer, Cell Biology
Gene ID (Entrez)
7038
Target Species
Human, Mouse, Rat
Form
Purified
Related Products
Description
- Thyroglobulin Monoclonal specifically detects Thyroglobulin in Human, Mouse, Rat samples
- It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.
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Antigen: Thyroglobulin
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Flow Cytometry 0.5-1ug/million cells in 0.1ml, Immunohistochemistry-Paraffin 0.1-0.2ug/ml
Gene Alias: AITD3TGN, TDH3, Tg, thyroglobulin
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: monoclonal antibody 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by monoclonal antibody 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-th
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Flow Cytometry, Immunohistochemistry (Paraffin)
Clone: 2H11
Conjugate: Unconjugated
Gene Accession No.: P01266
Gene Symbols: TG
Immunogen: Human thyroid follicular cells were used as immunogen to generate the antibody.
Quantity: 0.1 mg
Research Discipline: Cancer, Cell Biology
Gene ID (Entrez): 7038
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
Thyroglobulin
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Flow Cytometry 0.5-1ug/million cells in 0.1ml, Immunohistochemistry-Paraffin 0.1-0.2ug/ml
Gene Alias:
AITD3TGN, TDH3, Tg, thyroglobulin
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
monoclonal antibody 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by monoclonal antibody 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-th
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin)
Clone:
2H11
Conjugate:
Unconjugated
Gene Accession No.:
P01266
Gene Symbols:
TG
Immunogen:
Human thyroid follicular cells were used as immunogen to generate the antibody.
Quantity:
0.1 mg
Research Discipline:
Cancer, Cell Biology
Gene ID (Entrez):
7038
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: ACTH
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Flow Cytometry 0.5-1ug/million cells, ELISA, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml
Gene Alias: ACTH, adrenocorticotropic hormone, adrenocorticotropin, alpha-melanocyte-stimulating hormone, alpha-MSH, beta-endorphin, beta-LPH, beta-melanocyte-stimulating hormone, beta-MSH, CLIP, corticotropin-like intermediary peptide, corticotropin-lipotropin, gamma-LPH, gamma-MSH, lipotropin beta, lipotropin gamma, LPH, melanotropin alpha, melanotropin beta, melanotropin gamma, met-enkephalin, MSH, NPP, POC, pro-ACTH-endorphin, proopiomelanocortin, pro-opiomelanocortin, proopiomelanocortin preproprotein
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This monoclonal antibody is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinoma
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone: AH26
Conjugate: Unconjugated
Gene Accession No.: P01189
Gene Symbols: POMC
Immunogen: Synthetic peptide corresponding to aa1-24 of human ACTH (Uniprot: P01189)
Quantity: 0.1 mg
Research Discipline: Neuroscience, Nutrient Sensing in the Brain
Gene ID (Entrez): 5443
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
ACTH
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Flow Cytometry 0.5-1ug/million cells, ELISA, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml
Gene Alias:
ACTH, adrenocorticotropic hormone, adrenocorticotropin, alpha-melanocyte-stimulating hormone, alpha-MSH, beta-endorphin, beta-LPH, beta-melanocyte-stimulating hormone, beta-MSH, CLIP, corticotropin-like intermediary peptide, corticotropin-lipotropin, gamma-LPH, gamma-MSH, lipotropin beta, lipotropin gamma, LPH, melanotropin alpha, melanotropin beta, melanotropin gamma, met-enkephalin, MSH, NPP, POC, pro-ACTH-endorphin, proopiomelanocortin, pro-opiomelanocortin, proopiomelanocortin preproprotein
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This monoclonal antibody is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinoma
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Applications:
Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone:
AH26
Conjugate:
Unconjugated
Gene Accession No.:
P01189
Gene Symbols:
POMC
Immunogen:
Synthetic peptide corresponding to aa1-24 of human ACTH (Uniprot: P01189)
Quantity:
0.1 mg
Research Discipline:
Neuroscience, Nutrient Sensing in the Brain
Gene ID (Entrez):
5443
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: p53
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Western Blot 0.5-1ug/ml, Simple Western 10 ug/ml, Flow Cytometry 0.5-1ug/million cells in 0.1ml, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 1-2ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml
Gene Alias: Antigen NY-CO-13, FLJ92943, LFS1TRP53, p53, p53 tumor suppressor, P53cellular tumor antigen p53, Phosphoprotein p53, transformation-related protein 53, tumor protein p53, Tumor suppressor p53
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53
Content And Storage: Store at 4C.
Isotype: IgG2a κ
Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
Clone: BP53-12
Conjugate: Unconjugated
Gene Accession No.: P04637
Gene Symbols: TP53
Immunogen: Recombinant human wild-type p53 protein (Uniprot: P04637)
Quantity: 0.1 mg
Research Discipline: Apoptosis, Cancer, Cell Cycle and Replication, Cellular Markers, Checkpoint signaling, Core ESC Like Genes, DNA Double Strand Break Repair, DNA Repair, HIF Target Genes, Hypoxia, Neuroscience, Neurotransmission, p53 Pathway, Phospho Specific, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
Gene ID (Entrez): 7157
Target Species: Human, Mouse, Canine, Chicken, Hamster, Monkey, Mouse (Negative), Rat (Negative)
Form: Purified
Antigen:
p53
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Western Blot 0.5-1ug/ml, Simple Western 10 ug/ml, Flow Cytometry 0.5-1ug/million cells in 0.1ml, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 1-2ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml
Gene Alias:
Antigen NY-CO-13, FLJ92943, LFS1TRP53, p53, p53 tumor suppressor, P53cellular tumor antigen p53, Phosphoprotein p53, transformation-related protein 53, tumor protein p53, Tumor suppressor p53
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53
Content And Storage:
Store at 4C.
Isotype:
IgG2a κ
Applications:
Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
Clone:
BP53-12
Conjugate:
Unconjugated
Gene Accession No.:
P04637
Gene Symbols:
TP53
Immunogen:
Recombinant human wild-type p53 protein (Uniprot: P04637)
Quantity:
0.1 mg
Research Discipline:
Apoptosis, Cancer, Cell Cycle and Replication, Cellular Markers, Checkpoint signaling, Core ESC Like Genes, DNA Double Strand Break Repair, DNA Repair, HIF Target Genes, Hypoxia, Neuroscience, Neurotransmission, p53 Pathway, Phospho Specific, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
Gene ID (Entrez):
7157
Target Species:
Human, Mouse, Canine, Chicken, Hamster, Monkey, Mouse (Negative), Rat (Negative)
Form:
Purified
Antigen: Lambda Light Chain
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Western Blot 0.5-1 μg/mL, Flow Cytometry 0.5-1 μg/million cells, ELISA 1-5 μg/mL for coating, Immunohistochemistry 0.5-1 μg/mL, Immunocytochemistry/Immunofluorescence 1-2 μg/mL, Immunoprecipitation 1-2 μg/500 μg protein lysate, Immunohistochemistry-Paraffin 0.5-1 μg/mL, Immunohistochemistry-Frozen 0.5-1 μg/mL
Gene Alias: IGLC, immunoglobulin lambda constant group
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone: ICO-106
Conjugate: Unconjugated
Gene Accession No.: P01701, P01842
Gene Symbols: IGLC1
Immunogen: Human IgG was used as immunogen to generate the Lambda antibody.
Quantity: 0.1 mg
Research Discipline: Adaptive Immunity, Immunology
Gene ID (Entrez): 3536
Target Species: Human
Form: Purified
Antigen:
Lambda Light Chain
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Western Blot 0.5-1 μg/mL, Flow Cytometry 0.5-1 μg/million cells, ELISA 1-5 μg/mL for coating, Immunohistochemistry 0.5-1 μg/mL, Immunocytochemistry/Immunofluorescence 1-2 μg/mL, Immunoprecipitation 1-2 μg/500 μg protein lysate, Immunohistochemistry-Paraffin 0.5-1 μg/mL, Immunohistochemistry-Frozen 0.5-1 μg/mL
Gene Alias:
IGLC, immunoglobulin lambda constant group
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Applications:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone:
ICO-106
Conjugate:
Unconjugated
Gene Accession No.:
P01701, P01842
Gene Symbols:
IGLC1
Immunogen:
Human IgG was used as immunogen to generate the Lambda antibody.
Quantity:
0.1 mg
Research Discipline:
Adaptive Immunity, Immunology
Gene ID (Entrez):
3536
Target Species:
Human
Form:
Purified