NBP248084
Transglutaminase 2/TGM2 Antibody (SPM358) - IHC-Prediluted, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP248084-Each-of-1 | In Stock | ₹ 44,833.44 |
NBP248084 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,833.44
GST (18%): ₹ 8,070.019
Total Price: ₹ 52,903.459
Antigen
Transglutaminase 2/TGM2
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols
TGM2
Immunogen
Recombinant full-length human Transglutaminase 2/TGM2 protein (Uniprot: P21980)
Quantity
7 mL
Research Discipline
Apoptosis, Immune System Diseases, Immunology, Signal Transduction
Gene ID (Entrez)
7052
Target Species
Human, Mouse, Rat, Monkey, Rabbit
Form
Purified
Applications
Immunohistochemistry (Paraffin)
Clone
SPM358
Dilution
Immunohistochemistry-Paraffin
Gene Alias
C polypeptide, EC 2.3.2.13, G-ALPHA-h, protein-glutamine gamma-glutamyltransferase 2, protein-glutamine-gamma-glutamyltransferase, TG(C), TG2, TGase C, TGase H, TGase-2, TGase-H, TGCGNAH, Tissue transglutaminase, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), Transglutaminase C, Transglutaminase H, Transglutaminase-2
Host Species
Mouse
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Content And Storage
Store at 4C.
Isotype
IgG1 κ
Related Products
Description
- Transglutaminase 2/TGM2 Monoclonal specifically detects Transglutaminase 2/TGM2 in Human, Mouse, Rat, Monkey, Rabbit samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
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Antigen: Transglutaminase 2/TGM2
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: TGM2
Immunogen: Recombinant full-length human Transglutaminase 2/TGM2 protein (Uniprot: P21980)
Quantity: 7 mL
Research Discipline: Apoptosis, Immune System Diseases, Immunology, Signal Transduction
Gene ID (Entrez): 7052
Target Species: Human, Mouse, Rat, Monkey, Rabbit
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: SPM358
Dilution: Immunohistochemistry-Paraffin
Gene Alias: C polypeptide, EC 2.3.2.13, G-ALPHA-h, protein-glutamine gamma-glutamyltransferase 2, protein-glutamine-gamma-glutamyltransferase, TG(C), TG2, TGase C, TGase H, TGase-2, TGase-H, TGCGNAH, Tissue transglutaminase, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), Transglutaminase C, Transglutaminase H, Transglutaminase-2
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Antigen:
Transglutaminase 2/TGM2
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
TGM2
Immunogen:
Recombinant full-length human Transglutaminase 2/TGM2 protein (Uniprot: P21980)
Quantity:
7 mL
Research Discipline:
Apoptosis, Immune System Diseases, Immunology, Signal Transduction
Gene ID (Entrez):
7052
Target Species:
Human, Mouse, Rat, Monkey, Rabbit
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
SPM358
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
C polypeptide, EC 2.3.2.13, G-ALPHA-h, protein-glutamine gamma-glutamyltransferase 2, protein-glutamine-gamma-glutamyltransferase, TG(C), TG2, TGase C, TGase H, TGase-2, TGase-H, TGCGNAH, Tissue transglutaminase, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), Transglutaminase C, Transglutaminase H, Transglutaminase-2
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Antigen: Cytokeratin 18
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: KRT18
Immunogen: PMC-42 human breast carcinoma cells
Quantity: 7 mL
Research Discipline: Cancer, Cell Biology, Cellular Markers, Cytoskeleton Markers
Gene ID (Entrez): 3875
Target Species: Human, Bovine (Negative), Canine (Negative), Hamster (Negative), Mouse (Negative), Porcine (Negative), Rat (Negative)
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: B23.1
Dilution: Immunohistochemistry-Paraffin
Gene Alias: Cell proliferation-inducing gene 46 protein, cell proliferation-inducing protein 46, CK-18, CYK18, cytokeratin 18, cytokeratin-18, K18, keratin 18, keratin, type I cytoskeletal 18, keratin-18
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Antigen:
Cytokeratin 18
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
KRT18
Immunogen:
PMC-42 human breast carcinoma cells
Quantity:
7 mL
Research Discipline:
Cancer, Cell Biology, Cellular Markers, Cytoskeleton Markers
Gene ID (Entrez):
3875
Target Species:
Human, Bovine (Negative), Canine (Negative), Hamster (Negative), Mouse (Negative), Porcine (Negative), Rat (Negative)
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
B23.1
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
Cell proliferation-inducing gene 46 protein, cell proliferation-inducing protein 46, CK-18, CYK18, cytokeratin 18, cytokeratin-18, K18, keratin 18, keratin, type I cytoskeletal 18, keratin-18
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Antigen: Cytokeratin 19
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: KRT19
Immunogen: Recombinant human Cytokeratin 19 protein (Uniprot: P08727)
Quantity: 7 mL
Research Discipline: Cancer, Cell Biology, Cellular Markers, Cytoskeleton Markers, Neuroscience, Stem Cell Markers
Gene ID (Entrez): 3880
Target Species: Human
Form: Purified
Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone: KRT19/799
Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Alias: CK19, CK-19, cytokeratin 19, Cytokeratin-19,40-kDa keratin intermediate filament, K19cytokeratin-19, K1CS, keratin 19, keratin, type I cytoskeletal 19, keratin, type I, 40-kd, keratin-19, MGC15366
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a protein of 40kDa, identified as cytokeratin-19 (CK19), which is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
Content And Storage: Store at 4C.
Isotype: IgG2a λ
Antigen:
Cytokeratin 19
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
KRT19
Immunogen:
Recombinant human Cytokeratin 19 protein (Uniprot: P08727)
Quantity:
7 mL
Research Discipline:
Cancer, Cell Biology, Cellular Markers, Cytoskeleton Markers, Neuroscience, Stem Cell Markers
Gene ID (Entrez):
3880
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone:
KRT19/799
Dilution:
Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Alias:
CK19, CK-19, cytokeratin 19, Cytokeratin-19,40-kDa keratin intermediate filament, K19cytokeratin-19, K1CS, keratin 19, keratin, type I cytoskeletal 19, keratin, type I, 40-kd, keratin-19, MGC15366
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of 40kDa, identified as cytokeratin-19 (CK19), which is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
Content And Storage:
Store at 4C.
Isotype:
IgG2a λ
Antigen: c-Myc
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: MYC
Immunogen: A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-Myc, coupled to KLH. (Uniprot: P01106)
Quantity: 7 mL
Research Discipline: Autophagy, Cancer, Cancer Stem Cells, Cell Cycle and Replication, Chromatin Research, Core ESC Like Genes, Epigenetics, Epitope Tags, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
Gene ID (Entrez): 4609
Target Species: Human, Chicken (Negative), Mouse (Negative), Rat (Negative)
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: SPM237
Dilution: Immunohistochemistry-Paraffin
Gene Alias: avian myelocytomatosis viral oncogene homolog, BHLHE39, bHLHe39MRTL, Class E basic helix-loop-helix protein 39, c-Myc, MYC, myc proto-oncogene protein, MYCC, myc-related translation/localization regulatory factor, Proto-oncogene c-Myc, Transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog (avian)
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: It recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This monoclonal antibody shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Antigen:
c-Myc
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
MYC
Immunogen:
A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-Myc, coupled to KLH. (Uniprot: P01106)
Quantity:
7 mL
Research Discipline:
Autophagy, Cancer, Cancer Stem Cells, Cell Cycle and Replication, Chromatin Research, Core ESC Like Genes, Epigenetics, Epitope Tags, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
Gene ID (Entrez):
4609
Target Species:
Human, Chicken (Negative), Mouse (Negative), Rat (Negative)
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
SPM237
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
avian myelocytomatosis viral oncogene homolog, BHLHE39, bHLHe39MRTL, Class E basic helix-loop-helix protein 39, c-Myc, MYC, myc proto-oncogene protein, MYCC, myc-related translation/localization regulatory factor, Proto-oncogene c-Myc, Transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog (avian)
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
It recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This monoclonal antibody shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ