OP29L100UG
MilliporeSigma™ anti-p53 (Mutant) Clone: PAb240,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | OP29L100UG-Each-of-1 | In Stock | ₹ 40,486.99 |
OP29L100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,486.99
GST (18%): ₹ 7,287.658
Total Price: ₹ 47,774.648
Antigen
p53 (Mutant)
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Chicken, Hamster, Human, Mouse, Rat
Form
Purified
Applications
Flow Cytometry, Gel Supershift, Immunoblot, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clone
PAb240
Formulation
In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen
a recombinant protein consisting of amino acids 14-389 of p53 fused to β-galactosidase
Regulatory Status
RUO
Test Specificity
Recognizes the ∽53kDa mutant p53 protein under non-denaturing conditions by immunoprecipitation, immunofluorescence, and flow cytometry. Recognizes both mutant and wild-type p53 by immunoblotting and paraffin sections under denaturing conditions.
Content And Storage
2°C to 8°C
Isotype
IgG1
Related Products
Description
- Specifically detects p53 (Mutant) Clone: PAb240 in Bovine, Chicken, Hamster, Human, Mouse, Rat samples, and it is validated for Flow Cytometry, Gel Supershift, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno Blotting The human p53 tumor suppressor gene encodes a 393 amino acid phosphoprotein that exhibits sequence-specific DNA binding and directly interacts with various cellular and viral proteins
- p53 is the most commonly mutated gene in human cancer, with the majority of the mutations being amino acid substitutions
- The normal function of p53 is to effect cell cycle arrest at the G1 and G2 checkpoints in response to DNA damage
- This checkpoint function is executed by accumulation of p53 followed by induction of the GADD45, WAF1 and MDM2 genes
- The current model of p53 function postulates that p53 senses DNA damage and arrests the cell cycle in either the G1 or G2 phases to allow DNA repair to take place
- If repair is not successful, p53 initiates programmed cell death, thus preventing the propagation of genetic defects to successive generations of cells.
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Antigen: p53 (Mutant)
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Bovine, Chicken, Hamster, Human, Mouse, Rat
Form: Purified
Applications: Flow Cytometry, Gel Supershift, Immunoblot, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clone: PAb240
Formulation: In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen: a recombinant protein consisting of amino acids 14-389 of p53 fused to β-galactosidase
Regulatory Status: RUO
Test Specificity: Recognizes the ∽53kDa mutant p53 protein under non-denaturing conditions by immunoprecipitation, immunofluorescence, and flow cytometry. Recognizes both mutant and wild-type p53 by immunoblotting and paraffin sections under denaturing conditions.
Content And Storage: 2°C to 8°C
Isotype: IgG1
Antigen:
p53 (Mutant)
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Bovine, Chicken, Hamster, Human, Mouse, Rat
Form:
Purified
Applications:
Flow Cytometry, Gel Supershift, Immunoblot, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clone:
PAb240
Formulation:
In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen:
a recombinant protein consisting of amino acids 14-389 of p53 fused to β-galactosidase
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽53kDa mutant p53 protein under non-denaturing conditions by immunoprecipitation, immunofluorescence, and flow cytometry. Recognizes both mutant and wild-type p53 by immunoblotting and paraffin sections under denaturing conditions.
Content And Storage:
2°C to 8°C
Isotype:
IgG1
Antigen: p53 (Wild type)
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Bovine, Human, Mouse, Primate, Rat
Form: Purified
Applications: Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clone: PAb1620
Formulation: In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen: vLM mouse tumor cells
Regulatory Status: RUO
Test Specificity: Recognizes the ∽53kDa wild-type p53 protein in its native conformation in Hs27 cells and breast carcinoma tissue. Does not recognize mutant or denatured p53 protein.
Content And Storage: 2°C to 8°C
Isotype: IgG2a
Antigen:
p53 (Wild type)
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Bovine, Human, Mouse, Primate, Rat
Form:
Purified
Applications:
Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clone:
PAb1620
Formulation:
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen:
vLM mouse tumor cells
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽53kDa wild-type p53 protein in its native conformation in Hs27 cells and breast carcinoma tissue. Does not recognize mutant or denatured p53 protein.
Content And Storage:
2°C to 8°C
Isotype:
IgG2a
Antigen: Pan-Ras
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Purified
Applications: ELISA, Immunoblot, Immunoblot, Immunoprecipitation
Clone: DWP
Formulation: In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen: a synthetic peptide corresponding to amino acids 5-16 of Ras (H, K, or N) with Val at position 12
Regulatory Status: RUO
Test Specificity: Recognizes the ∽21kDa H-, K-, and N-Ras proteins.
Content And Storage: 2°C to 8°C
Isotype: IgG2b
Antigen:
Pan-Ras
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Purified
Applications:
ELISA, Immunoblot, Immunoblot, Immunoprecipitation
Clone:
DWP
Formulation:
In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen:
a synthetic peptide corresponding to amino acids 5-16 of Ras (H, K, or N) with Val at position 12
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽21kDa H-, K-, and N-Ras proteins.
Content And Storage:
2°C to 8°C
Isotype:
IgG2b
Antigen: c-ErbB2/c-Neu
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Flow Cytometry, Immunoblot, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation
Clone: TA-1
Formulation: In 50mM PBS, 0.2% gelatin, pH 7.5.
Immunogen: cells overexpressing human c-ErbB2/c-Neu
Regulatory Status: RUO
Test Specificity: Recognizes the ∽185kDa c-ErbB2/c-Neu protein in SK-BR-3 cells.
Content And Storage: 2°C to 8°C
Isotype: IgG1
Antigen:
c-ErbB2/c-Neu
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, Immunoblot, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation
Clone:
TA-1
Formulation:
In 50mM PBS, 0.2% gelatin, pH 7.5.
Immunogen:
cells overexpressing human c-ErbB2/c-Neu
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽185kDa c-ErbB2/c-Neu protein in SK-BR-3 cells.
Content And Storage:
2°C to 8°C
Isotype:
IgG1