PA126616
Granzyme B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA126616-Each-of-1 | In Stock | ₹ 56,041.80 |
PA126616 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 56,041.80
GST (18%): ₹ 10,087.524
Total Price: ₹ 66,129.324
Antigen
Granzyme B
Classification
Polyclonal
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P10144
Gene Symbols
GZMB
Immunogen
Synthetic peptide corresponding to residues E(20) I I G G H E A K P H S R P Y M A Y L(38) of human Granzyme B.
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Gene
GZMB
Gene Alias
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species
Rabbit
Purification Method
IgG fraction
Regulatory Status
RUO
Gene ID (Entrez)
3002
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- For IHC (paraffin) procedures perform heat mediated antigen retrieval using 10mM citrate buffer (p.H
- 6.0) before commencing with the IHC staining protocol
- Positive Control: Tonsil Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells
- Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells
- Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells
- The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis
- Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis
- Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein
- Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells
- A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
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Antigen: Granzyme B
Classification: Polyclonal
Formulation: PBS with 0.09% sodium azide
Gene Accession No.: P10144
Gene Symbols: GZMB
Immunogen: Synthetic peptide corresponding to residues E(20) I I G G H E A K P H S R P Y M A Y L(38) of human Granzyme B.
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Gene: GZMB
Gene Alias: AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species: Rabbit
Purification Method: IgG fraction
Regulatory Status: RUO
Gene ID (Entrez): 3002
Content And Storage: 4° C, do not freeze
Form: Liquid
Antigen:
Granzyme B
Classification:
Polyclonal
Formulation:
PBS with 0.09% sodium azide
Gene Accession No.:
P10144
Gene Symbols:
GZMB
Immunogen:
Synthetic peptide corresponding to residues E(20) I I G G H E A K P H S R P Y M A Y L(38) of human Granzyme B.
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Gene:
GZMB
Gene Alias:
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species:
Rabbit
Purification Method:
IgG fraction
Regulatory Status:
RUO
Gene ID (Entrez):
3002
Content And Storage:
4° C, do not freeze
Form:
Liquid
Antigen: M13 Phage coat protein
Classification: Polyclonal
Formulation: 0.01M PBS with 15mM sodium azide; pH 7.4
Gene Accession No.: __
Gene Symbols: __
Immunogen: fd bacteriophage.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Virus
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunohistochemistry
Conjugate: Unconjugated
Gene: __
Gene Alias: Attachment protein G3P, G3P, Gene 3 protein, III, Minor coat protein
Host Species: Rabbit
Purification Method: IgG fraction
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
M13 Phage coat protein
Classification:
Polyclonal
Formulation:
0.01M PBS with 15mM sodium azide; pH 7.4
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
fd bacteriophage.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Virus
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunohistochemistry
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
Attachment protein G3P, G3P, Gene 3 protein, III, Minor coat protein
Host Species:
Rabbit
Purification Method:
IgG fraction
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: FITC
Classification: Polyclonal
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: __
Gene Symbols: __
Immunogen: Fluorescein, conjugated to goat IgG.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Chemical
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunodiffusion, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: __
Gene Alias: Fluorescein
Host Species: Goat
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
FITC
Classification:
Polyclonal
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
Fluorescein, conjugated to goat IgG.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Chemical
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunodiffusion, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
Fluorescein
Host Species:
Goat
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: IL-6
Classification: Polyclonal
Formulation: whole serum diluted in 0.02M potassium phosphate with 0.15M NaCl and no preservative; pH 7.2
Gene Accession No.: P05231
Gene Symbols: Il6
Immunogen: Recombinant human IL6, expressed in E.coli.
Quantity: 200 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: Il6
Gene Alias: B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
Host Species: Rabbit
Purification Method: __
Regulatory Status: RUO
Gene ID (Entrez): 3569
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
IL-6
Classification:
Polyclonal
Formulation:
whole serum diluted in 0.02M potassium phosphate with 0.15M NaCl and no preservative; pH 7.2
Gene Accession No.:
P05231
Gene Symbols:
Il6
Immunogen:
Recombinant human IL6, expressed in E.coli.
Quantity:
200 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
Il6
Gene Alias:
B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
Host Species:
Rabbit
Purification Method:
__
Regulatory Status:
RUO
Gene ID (Entrez):
3569
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid