PC41100UG
MilliporeSigma™ anti-Cathepsin B, Polyclonal
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PC41100UG-Each-of-1 | In Stock | ₹ 38,734.72 |
PC41100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
Cathepsin B
Classification
Polyclonal
Formulation
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen
purified human liver cathepsin B
Regulatory Status
RUO
Test Specificity
Recognizes the ∽43kDa latent and the ∽31kDa active forms of cathepsin B in breast carcinoma tissues.
Content And Storage
2°C to 8°C
Isotype
IgG
Applications
Immunohistochemistry (Paraffin)
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects Cathepsin B Clone: in Human samples, and it is validated for Immunohistochemistry (Paraffin) Cathepsin B (CB) is a normal lysosomal proteinase which is expressed in all cells
- It is a cysteine endoproteinase which is structurally and functionally related to the papain family of proteinases
- CB is synthesized as an inactive∽43kDa pro-enzyme which, by removal of a 62 amino acid propeptide, is activated to the single-chain form of∽31kDa or the two-chain form (∽25 and∽5kDa subunits)
- Mature CB is normally localized in the lysosomes where it functions in protein turnover
- It has also been shown to be capable of degrading extracellular matrix proteins at acidic and neutral pH
- Endogenous inhibitors of cysteine proteinases, the cystatins and stefins, may play a major role in regulating their activity
- In tumor cells and in cells exposed to mitogens, CB displays altered cellular trafficking resulting in the secretion of the∽43kDa precursor
- Elevated levels of CB correlate with malignancy suggesting that this enzyme may be a useful prognostic marker for several types of human cancers.
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Antigen: Cathepsin B
Classification: Polyclonal
Formulation: In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen: purified human liver cathepsin B
Regulatory Status: RUO
Test Specificity: Recognizes the ∽43kDa latent and the ∽31kDa active forms of cathepsin B in breast carcinoma tissues.
Content And Storage: 2°C to 8°C
Isotype: IgG
Applications: Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Cathepsin B
Classification:
Polyclonal
Formulation:
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen:
purified human liver cathepsin B
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽43kDa latent and the ∽31kDa active forms of cathepsin B in breast carcinoma tissues.
Content And Storage:
2°C to 8°C
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: Vanilloid Receptor Like Protein-1 (744-761)
Classification: Polyclonal
Formulation: 100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
Immunogen: a synthetic peptide (KNSASEEDHLPLQVLQSP) corresponding to amino acids 744-761 of rat vanilloid receptor like protein 1, conjugated to KLH
Regulatory Status: RUO
Test Specificity: Recognizes the ∽98kDa (doublet) vanilloid receptor like protein-1 in rat spinal cord extract. Supplied with a control peptide (100μg size only).
Content And Storage: 2°C to 8°C
Isotype: IgG
Applications: Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 1 Set
Primary or Secondary: Primary
Target Species: Mouse, Rat
Form: Purified
Antigen:
Vanilloid Receptor Like Protein-1 (744-761)
Classification:
Polyclonal
Formulation:
100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
Immunogen:
a synthetic peptide (KNSASEEDHLPLQVLQSP) corresponding to amino acids 744-761 of rat vanilloid receptor like protein 1, conjugated to KLH
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽98kDa (doublet) vanilloid receptor like protein-1 in rat spinal cord extract. Supplied with a control peptide (100μg size only).
Content And Storage:
2°C to 8°C
Isotype:
IgG
Applications:
Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
1 Set
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Form:
Purified
Antigen: Caspase-3, Cleaved
Classification: Polyclonal
Formulation: In PBS, 50% glycerol, 1% BSA, pH 7.2.
Immunogen: a synthetic peptide corresponding to amino acids surrounding the Asp175cleavage site of caspase-3
Regulatory Status: RUO
Test Specificity: Recognizes the ∽17kDa cleaved fragment of caspase-3.
Content And Storage: ≤ -70°C
Isotype: IgG
Applications: Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
Caspase-3, Cleaved
Classification:
Polyclonal
Formulation:
In PBS, 50% glycerol, 1% BSA, pH 7.2.
Immunogen:
a synthetic peptide corresponding to amino acids surrounding the Asp175cleavage site of caspase-3
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽17kDa cleaved fragment of caspase-3.
Content And Storage:
≤ -70°C
Isotype:
IgG
Applications:
Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: MYH (33-51)
Classification: Polyclonal
Formulation: Undiluted serum.
Immunogen: a synthetic peptide (QEGRQKHAKNNSQAKPSAC) corresponding to amino acids 33-51 of human MYH
Regulatory Status: RUO
Test Specificity: Recognizes the MYH protein and several of its approximately 10 isoforms in PC12, Jurkat, and HeLa cells.
Content And Storage: −20°C
Isotype: IgG
Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Form: Undiluted
Antigen:
MYH (33-51)
Classification:
Polyclonal
Formulation:
Undiluted serum.
Immunogen:
a synthetic peptide (QEGRQKHAKNNSQAKPSAC) corresponding to amino acids 33-51 of human MYH
Regulatory Status:
RUO
Test Specificity:
Recognizes the MYH protein and several of its approximately 10 isoforms in PC12, Jurkat, and HeLa cells.
Content And Storage:
−20°C
Isotype:
IgG
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Form:
Undiluted