PIPA5143631
Phospho-MERTK (Tyr749, Tyr753, Tyr754) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143631-Each-of-1 | In Stock | ₹ 38,416.44 |
PIPA5143631 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,416.44
GST (18%): ₹ 6,914.959
Total Price: ₹ 45,331.399
Antigen
Phospho-MERTK (Tyr749, Tyr753, Tyr754)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Mertk
Gene Alias
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10461, 17289, 65037
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Western Blot
Concentration
0.4 mg/mL
Formulation
10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
P57097, Q12866, Q60805
Gene Symbols
Mertk
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr749/753/754 of human MerTK, conjugated to keyhole limpet hemocyanin (KLH).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- Specific for the ∽160 kDa MerTK protein phosphorylated at Tyr749/753/754
- The immunolabeling is completely eliminated by treatment with lambda-phosphatase
- Due to post-translational modifications of the Mer protein, a significant shift in molecular weight is seen from the predicted molecular weight of 110 kDa
- For optimal results immunoprecipitation is recommended due to the 91% homology of the related receptor tyrosine kinase, Axl, that runs at ∽140 kDa
- MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease
- Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis)
- Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules
- Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1
- MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment
- Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis
- Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
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Antigen: Phospho-MERTK (Tyr749, Tyr753, Tyr754)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Mertk
Gene Alias: c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10461, 17289, 65037
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Western Blot
Concentration: 0.4 mg/mL
Formulation: 10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: P57097, Q12866, Q60805
Gene Symbols: Mertk
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr749/753/754 of human MerTK, conjugated to keyhole limpet hemocyanin (KLH).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-MERTK (Tyr749, Tyr753, Tyr754)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Mertk
Gene Alias:
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10461, 17289, 65037
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Western Blot
Concentration:
0.4 mg/mL
Formulation:
10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
P57097, Q12866, Q60805
Gene Symbols:
Mertk
Immunogen:
Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr749/753/754 of human MerTK, conjugated to keyhole limpet hemocyanin (KLH).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: PGP9.5
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Uchl1
Gene Alias: AW822034; C88048; epididymis luminal protein 117; epididymis secretory protein Li 53; gad; gracile axonal dystrophy; HEL-117; HEL-S-53; MGC133697 protein; NDGOA; neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; PARK5; PGP 9.5; PGP9.5; PGP95; protein gene product 9.5; R75593; ubiquitin carboxyl-terminal esterase; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase L1; ubiquitin carboxy-terminal hydrolase L1; ubiquitin C-terminal hydrolase; ubiquitin C-terminal hydrolase 1; ubiquitin C-terminal hydrolase L1; ubiquitin thioesterase L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1; UCHL; UCHL1; UCH-L1; UCHL-1
Host Species: Chicken
Purification Method: IgY fraction
Regulatory Status: RUO
Gene ID (Entrez): 22223, 514394, 7345
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgY
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Concentration: Lot-Specific
Formulation: PBS with 10mM sodium azide
Gene Accession No.: P09936, P23356, Q9R0P9
Gene Symbols: Uchl1
Immunogen: Recombinant full length human UCHL1 purified from E. coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Human, Mouse
Form: Liquid
Antigen:
PGP9.5
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Uchl1
Gene Alias:
AW822034; C88048; epididymis luminal protein 117; epididymis secretory protein Li 53; gad; gracile axonal dystrophy; HEL-117; HEL-S-53; MGC133697 protein; NDGOA; neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; PARK5; PGP 9.5; PGP9.5; PGP95; protein gene product 9.5; R75593; ubiquitin carboxyl-terminal esterase; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase L1; ubiquitin carboxy-terminal hydrolase L1; ubiquitin C-terminal hydrolase; ubiquitin C-terminal hydrolase 1; ubiquitin C-terminal hydrolase L1; ubiquitin thioesterase L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1; UCHL; UCHL1; UCH-L1; UCHL-1
Host Species:
Chicken
Purification Method:
IgY fraction
Regulatory Status:
RUO
Gene ID (Entrez):
22223, 514394, 7345
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgY
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Concentration:
Lot-Specific
Formulation:
PBS with 10mM sodium azide
Gene Accession No.:
P09936, P23356, Q9R0P9
Gene Symbols:
Uchl1
Immunogen:
Recombinant full length human UCHL1 purified from E. coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Human, Mouse
Form:
Liquid
Antigen: Pre-Pro-Vasopressin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: AVP
Gene Alias: ARVP; VP
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11998, 24221, 551
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: Lot-Specific
Formulation: 10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: P01185, P01186, P35455
Gene Symbols: AVP
Immunogen: Synthetic peptide corresponding to key amino acid residues surrounding the cleavage sites for the human vasopressin precursor peptide, conjugated to keyhole limpet hemocyanin (KLH).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Pre-Pro-Vasopressin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
AVP
Gene Alias:
ARVP; VP
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11998, 24221, 551
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
Lot-Specific
Formulation:
10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
P01185, P01186, P35455
Gene Symbols:
AVP
Immunogen:
Synthetic peptide corresponding to key amino acid residues surrounding the cleavage sites for the human vasopressin precursor peptide, conjugated to keyhole limpet hemocyanin (KLH).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: Phospho-c-Abl (Tyr245)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ABL1
Gene Alias: Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl; Abl 1 antib; ABL proto-oncogene 1, non-receptor tyrosine kinase; Abl1; ABL2; ABLL; AI325092; ARG; B30; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-ABL1; E430008G22Rik; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11350, 25, 311860
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Western Blot
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P00519, P00520
Gene Symbols: ABL1
Immunogen: Phospho-c-Abl (Tyr-245) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 245 of human c-Abl. This peptide sequence has high homology to the conserved site in rat and mouse c-Abl, as well as in viral Abl and BCR-Abl fusion protein.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-c-Abl (Tyr245)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ABL1
Gene Alias:
Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl; Abl 1 antib; ABL proto-oncogene 1, non-receptor tyrosine kinase; Abl1; ABL2; ABLL; AI325092; ARG; B30; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-ABL1; E430008G22Rik; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11350, 25, 311860
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Western Blot
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P00519, P00520
Gene Symbols:
ABL1
Immunogen:
Phospho-c-Abl (Tyr-245) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 245 of human c-Abl. This peptide sequence has high homology to the conserved site in rat and mouse c-Abl, as well as in viral Abl and BCR-Abl fusion protein.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid