PIPA597330
Phospho-Chk1 (Ser280) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA597330-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA597330 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Phospho-Chk1 (Ser280)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Chek1
Gene Alias
C85740, Cell cycle checkpoint kinase, checkpoint kinase 1, checkpoint kinase 1 homolog, checkpoint kinase-1, Checkpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog, Chk1-S, homolog of Chk1-S, HRD1 Protein, rad27, rad27 homolog, serine/threonine protein kinase CHK1, serine/threonine-protein kinase Chk1, Synoviolin, YBR1742, YBR274W
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1111, 12649, 140583
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.66 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
O14757, O35280, Q91ZN7
Gene Symbols
Chek1
Immunogen
A synthetic phosphorylated peptide around S280 of human Chk1 (NP_0012652)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HT-29; Cellular Location: Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center Immunogen sequence: VTSGG CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised
- CHK1 is a key mediator in the DNA damage-induced checkpoint network
- CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress
- When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase
- Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
Compare Similar Items
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Antigen: Phospho-Chk1 (Ser280)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Chek1
Gene Alias: C85740, Cell cycle checkpoint kinase, checkpoint kinase 1, checkpoint kinase 1 homolog, checkpoint kinase-1, Checkpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog, Chk1-S, homolog of Chk1-S, HRD1 Protein, rad27, rad27 homolog, serine/threonine protein kinase CHK1, serine/threonine-protein kinase Chk1, Synoviolin, YBR1742, YBR274W
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1111, 12649, 140583
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.66 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: O14757, O35280, Q91ZN7
Gene Symbols: Chek1
Immunogen: A synthetic phosphorylated peptide around S280 of human Chk1 (NP_0012652)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-Chk1 (Ser280)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Chek1
Gene Alias:
C85740, Cell cycle checkpoint kinase, checkpoint kinase 1, checkpoint kinase 1 homolog, checkpoint kinase-1, Checkpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog, Chk1-S, homolog of Chk1-S, HRD1 Protein, rad27, rad27 homolog, serine/threonine protein kinase CHK1, serine/threonine-protein kinase Chk1, Synoviolin, YBR1742, YBR274W
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1111, 12649, 140583
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.66 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
O14757, O35280, Q91ZN7
Gene Symbols:
Chek1
Immunogen:
A synthetic phosphorylated peptide around S280 of human Chk1 (NP_0012652)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-CREB (Ser133)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CREB1
Gene Alias: 2310001E10Rik, 3526402H21Rik, active transcription factor CREB, AV083133, cAMP response element binding protein 1, cAMP responsive element binding protein 1, cAMP-response element-binding protein-1, cAMP-responsive element-binding protein 1, CREB, CREB1, Creb-1, cyclic adenosine 3',5'-monophosphate response element-binding protein CREB, cyclic AMP-responsive element-binding protein 1, htCREB, MGC9284, OTTHUMP00000206661, OTTHUMP00000206662, OTTHUMP00000206667, transactivator protein, Y protein
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12912, 1385, 81646
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.44 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P15337, P16220, Q01147
Gene Symbols: CREB1
Immunogen: A synthetic phosphorylated peptide around S133 of human CREB1 (NP_6043911)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-CREB (Ser133)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CREB1
Gene Alias:
2310001E10Rik, 3526402H21Rik, active transcription factor CREB, AV083133, cAMP response element binding protein 1, cAMP responsive element binding protein 1, cAMP-response element-binding protein-1, cAMP-responsive element-binding protein 1, CREB, CREB1, Creb-1, cyclic adenosine 3',5'-monophosphate response element-binding protein CREB, cyclic AMP-responsive element-binding protein 1, htCREB, MGC9284, OTTHUMP00000206661, OTTHUMP00000206662, OTTHUMP00000206667, transactivator protein, Y protein
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12912, 1385, 81646
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.44 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P15337, P16220, Q01147
Gene Symbols:
CREB1
Immunogen:
A synthetic phosphorylated peptide around S133 of human CREB1 (NP_6043911)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-ATF (Thr71)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Atf2
Gene Alias: Activating 2, Activating transcription factor 2, activating transcription factor 2 splice variant ATF2-var2, ATF2, Atf-2, cAMP response element-binding protein CRE-BP1, cAMP responsive element binding protein 2, formerly, cAMP-dependent transcription factor ATF-2, CREB2, CREB-2, CRE-BP, CREBP1, CRE-BP1, Cyclic AMP-dependent transcription factor ATF-2, cyclic AMP-responsive element-binding protein 2, D130078H02Rik, D18875, HB16, Histone acetyltransferase ATF2, MGC111558, mXBP, MXBP protein, OTTHUMP00000205345, OTTHUMP00000205347, OTTHUMP00000205348, OTTHUMP00000205350, OTTHUMP00000205352, OTTHUMP00000205353, OTTHUMP00000205354, Tg(Gzma-Klra1)7Wum, TREB7
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11909, 1386, 81647
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 3.24 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P15336, P16951, Q00969
Gene Symbols: Atf2
Immunogen: A synthetic phosphorylated peptide around T71 of human ATF2 (NP_0018712)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-ATF (Thr71)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Atf2
Gene Alias:
Activating 2, Activating transcription factor 2, activating transcription factor 2 splice variant ATF2-var2, ATF2, Atf-2, cAMP response element-binding protein CRE-BP1, cAMP responsive element binding protein 2, formerly, cAMP-dependent transcription factor ATF-2, CREB2, CREB-2, CRE-BP, CREBP1, CRE-BP1, Cyclic AMP-dependent transcription factor ATF-2, cyclic AMP-responsive element-binding protein 2, D130078H02Rik, D18875, HB16, Histone acetyltransferase ATF2, MGC111558, mXBP, MXBP protein, OTTHUMP00000205345, OTTHUMP00000205347, OTTHUMP00000205348, OTTHUMP00000205350, OTTHUMP00000205352, OTTHUMP00000205353, OTTHUMP00000205354, Tg(Gzma-Klra1)7Wum, TREB7
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11909, 1386, 81647
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
3.24 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P15336, P16951, Q00969
Gene Symbols:
Atf2
Immunogen:
A synthetic phosphorylated peptide around T71 of human ATF2 (NP_0018712)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-EGFR (Tyr845)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EGFR
Gene Alias: 2.7.10.1, 9030024J15Rik, AI552599, avian erythroblastic leukemia viral (v-erbB) oncogene homolog, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10.1, egf receptor, Egfr, EGFR-related peptide, epidermal growth factor receptor, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1), epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1), ERBB, ERBB1, ErbB-1, erb-b2 receptor tyrosine kinase 1, Errb1, Errp, HER1, kinase EGFR, mENA, NISBD2, Oncogene ERBB, PIG61, Proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, Urogastrone, wa2, wa-2, Wa5, waved 2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1956
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.53 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P00533
Gene Symbols: EGFR
Immunogen: A synthetic phosphorylated peptide around Y845 of human EGFR (NP_0052192)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-EGFR (Tyr845)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EGFR
Gene Alias:
2.7.10.1, 9030024J15Rik, AI552599, avian erythroblastic leukemia viral (v-erbB) oncogene homolog, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10.1, egf receptor, Egfr, EGFR-related peptide, epidermal growth factor receptor, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1), epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1), ERBB, ERBB1, ErbB-1, erb-b2 receptor tyrosine kinase 1, Errb1, Errp, HER1, kinase EGFR, mENA, NISBD2, Oncogene ERBB, PIG61, Proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, Urogastrone, wa2, wa-2, Wa5, waved 2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1956
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.53 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P00533
Gene Symbols:
EGFR
Immunogen:
A synthetic phosphorylated peptide around Y845 of human EGFR (NP_0052192)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG