75-791-0

Tocris Bioscience™ Olaparib

Manufacturer: Fischer Scientific

CAS Number: 763113-22-0

Select a Size

Pack Size SKU Availability Price
Each of 1 75-791-0-Each-of-1 In Stock ₹ 9,282.70

75-791-0 - Each of 1

₹ 9,282.70

In Stock

Quantity

1

Base Price: ₹ 9,282.70

GST (18%): ₹ 1,670.886

Total Price: ₹ 10,953.586

Chemical Name or Material

4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone

Quantity

10 mg

Molecular Formula

C24H23FN4O3

CAS

763113-22-0

Target

Poly(ADP-ribose) Polymerase Inhibitors

Purity

0.98

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Description

  • Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively)
  • Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates
  • BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells
  • Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat
  • No
  • 2706) in xenograft mouse model
  • Olaparib is orally bioavailable in rats.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C