7223006
Tocris Bioscience™ Olaparib
Potent PARP inhibitor
Manufacturer: Fischer Scientific
CAS Number: 763113-22-0
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Chemical Name or Material
4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone
Target
Poly(ADP-ribose) Polymerase Inhibitors
Purity
0.98
CAS
763113-22-0
Molecular Formula
C24H23FN4O3
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Description
- Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively)
- Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates
- BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells
- Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat
- No
- 2706) in xenograft mouse model
- Olaparib is orally bioavailable in rats.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone
Target: Poly(ADP-ribose) Polymerase Inhibitors
Purity: 0.98
CAS: 763113-22-0
Molecular Formula: C24H23FN4O3
Chemical Name or Material:
4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone
Target:
Poly(ADP-ribose) Polymerase Inhibitors
Purity:
0.98
CAS:
763113-22-0
Molecular Formula:
C24H23FN4O3
Chemical Name or Material: (1 R,3 R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1 H-pyrido[3,4-b]indole-3-carboxylate
Target: Glutathione Peroxidase 4/GPX4
Purity: 0.98
CAS: 1219810-15-7
Molecular Formula: C23H21ClN2O5
Chemical Name or Material:
(1 R,3 R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1 H-pyrido[3,4-b]indole-3-carboxylate
Target:
Glutathione Peroxidase 4/GPX4
Purity:
0.98
CAS:
1219810-15-7
Molecular Formula:
C23H21ClN2O5
Chemical Name or Material: N-[1-[[2,4-bis(Trifluoromethyl)phenyl]methyl]-1 H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide
Target: Other ER Stress/UPR Activators
Purity: 0.98
CAS: 2323027-38-7
Molecular Formula: C20H12F6N4O3
Chemical Name or Material:
N-[1-[[2,4-bis(Trifluoromethyl)phenyl]methyl]-1 H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide
Target:
Other ER Stress/UPR Activators
Purity:
0.98
CAS:
2323027-38-7
Molecular Formula:
C20H12F6N4O3
Chemical Name or Material: N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide
Target: Brutons Tyrosine Kinase (BTK) Inhibitors
Purity: 0.97
CAS: 910232-84-7
Molecular Formula: C34H37N5O4
Chemical Name or Material:
N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide
Target:
Brutons Tyrosine Kinase (BTK) Inhibitors
Purity:
0.97
CAS:
910232-84-7
Molecular Formula:
C34H37N5O4