SML2219
SGC-AAK1-1
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 2247894-32-0
Synonym(S): N-(6-(3-(N,N-Diethylsulfamoylamino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML2219-5-MG | In Stock | ₹ 11,940.00 |
| 25 MG | SML2219-25-MG | In Stock | ₹ 38,450.00 |
SML2219 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 11,940.00
GST (18%): ₹ 2,149.20
Total Price: ₹ 14,089.20
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CCN(CC)S(NC1=CC=CC(C2=CC(NN=C3NC(C4CC4)=O)=C3C=C2)=C1)(=O)=O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | eMolecules Medchem Express / SGC-AAK1-1 / 5mg / 532149827 / HY-123940 / / 2247894-32-0 / [null] / 427.520 / C21H25N5O3S | eMolecules | ₹ 10,075.55 | |
 | SGC-AAK1-1 | ChemScene | ₹ 9,582.72 - ₹ 41,496.60 | |
 | 2247894-32-0 | SGC AAK1 1 | A2B Chem | ₹ 6,074.76 - ₹ 48,598.08 |
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Description
- Biochem/physiol Actions: SGC-AAK1-1 is an ATP-competitive kinase inhibitor against AP2-associated protein kinase 1/AAK1 and BMP-2-inducible protein kinase/BIKE/BMP2K (Ki = 9.1 & 17 nM, respectively, by ATP site fluorescent tracer displacement assay; AAK1 IC50 = 270 nM by coupled enzyme assay). SGC-AAK1-1 downregulates cellular AP2M1 Thr156 phosphorylation level in a dose-dependent manner (ECmax ∼12.5 μM) without detectable cytotoxicity. Selectivity profiling identifies only 5 additional kinases among a panel of ∼400 with >50% inhibition by 1 μM SGC-AAK1-1 (KD = 72 nM/RIOK1, 290 nM/RIOK3, 260 nM/PIP5K1C, 880 nM/CDKL1, 960 nM/MYLK2 by DiscoverX KINOMEscan). SGC-AAK1-1N is a structure analog and the recommended negative control (IC50 = 11 μM by AAK1 activity assay; KD = 8.8 μM/AAK1 & >10 μM/BIKE vs. KD = 26 nM/AAK1 & 930 nM/BIKE with SGC-AAK1-1 by DiscoverX). For characterization details of SGC-AAK1-1, please visit the SGC-AAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.SGC-AAK1-1N is the negative control for the active probe, SGC-AAK1-1. SGC-AAK1-1N is available from Sigma. To learn more about and purchase SGC-AAK1-1N, click here.To learn about other SGC chemical probes, visit sigma.com/sgc
- Features and Benefits: SGC-AAK1-1 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: 2-8°C
SMILES string: CCN(CC)S(NC1=CC=CC(C2=CC(NN=C3NC(C4CC4)=O)=C3C=C2)=C1)(=O)=O
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
CCN(CC)S(NC1=CC=CC(C2=CC(NN=C3NC(C4CC4)=O)=C3C=C2)=C1)(=O)=O
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: 2-8°C
SMILES string: O=C(C(C)C)NC1=NNC2=C1C=CC(C3=CC(NS(C4CC4)(=O)=O)=CC=C3)=C2
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
O=C(C(C)C)NC1=NNC2=C1C=CC(C3=CC(NS(C4CC4)(=O)=O)=CC=C3)=C2
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: 2-8°C
SMILES string: O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: −20°C
SMILES string: O=C1C[C@H](C)N(C(N2CC(C3)C3C2)=O)C4=CC=C(C(NCCC5CC5)=O)C=C4N1
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
−20°C
SMILES string:
O=C1C[C@H](C)N(C(N2CC(C3)C3C2)=O)C4=CC=C(C(NCCC5CC5)=O)C=C4N1