Ketoconazole
99.0-101.0% (EP, titration)
Manufacturer: Sigma Aldrich
CAS Number: 65277-42-1
Synonym(S): (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | K1003-100-MG | In Stock | ₹ 21,834.03 |
K1003 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 21,834.03
GST (18%): ₹ 3,930.125
Total Price: ₹ 25,764.155
description
Specific Optical Rotation (EP): (−0.10) ∼ +0.10 °
Quality Level
200
Assay
99.0-101.0% (EP, titration)
form
powder
color
white to off-white
antibiotic activity spectrum
Gram-positive bacteriafungiyeast
Mode of action
enzyme | inhibits
storage temp.
2-8°C
SMILES string
CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2
InChI
1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Ketoconazole Impurity Standard, MilliporeSigma™ Supelco™ | MilliporeSigma Supelco | ₹ 25,240.20 | |
 | Selleck Chemical LLC Ketoconazole 100mg 65277-42-1 | Selleck Chemical LLC | ₹ 15,092.78 | |
| | Ketoconazole Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™ | MilliporeSigma Supelco | ₹ 11,516.38 | |
 | Sigma Aldrich Fine Chemicals Biosciences Ketoconazole United States Pharmacopeia (USP) Reference Standard | 65277-42-1 | MFCD00058579 | 200MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 45,791.71 | |
 | Sigma Aldrich Fine Chemicals Biosciences Ketoconazole | 65277-42-1 | MFCD00058579 | 5MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 31,338.92 | |
 | Ketoconazole | Supelco | ₹ 9,190.43 | |
| | Ketoconazole impurity standard | Sigma Aldrich | ₹ 22,018.05 | |
 | Ketoconazole solution | Supelco | ₹ 20,096.30 | |
| | Ketoconazole | Sigma Aldrich | ₹ 21,834.03 | |
 | Piperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis- | Aaron Chemicals LLC | ₹ 256.68 - ₹ 16,085.28 |
Related Products
Description
- General description: Chemical structure: imidazole
- Application: Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model[1], to study interleukin 1 mediated antitumor effects[2], and drug interactions in vivo[3]
- Biochem/physiol Actions: Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - STOT RE 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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description: Specific Optical Rotation (EP): (−0.10) ∼ +0.10 °
Quality Level: 200
Assay: 99.0-101.0% (EP, titration)
form: powder
color: white to off-white
antibiotic activity spectrum: Gram-positive bacteriafungiyeast
Mode of action: enzyme | inhibits
storage temp.: 2-8°C
SMILES string: CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2
InChI: 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
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