Josamycin
≥90% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 16846-24-5
Synonym(S): Leucomycin A3
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 59983-50-MG | In Stock | ₹ 6,289.33 |
59983 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 6,289.33
GST (18%): ₹ 1,132.079
Total Price: ₹ 7,421.409
Quality Level
200
Assay
≥90% (HPLC)
form
powder
color
white to slightly yellow
antibiotic activity spectrum
Gram-positive bacteria
Mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)OC(C)=O
InChI
1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1
InChI key
XJSFLOJWULLJQS-NGVXBBESSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences Josamycin European Pharmacopoeia (EP) Reference Standard | 16846-24-5 | MFCD00211043 | | Sigma Aldrich Fine Chemicals Biosciences | ₹ 23,582.90 | |
 | Sigma Aldrich Fine Chemicals Biosciences Josamycin for peak identification European Pharmacopoeia (EP) Reference Standard | 16846-24-5 | MFCD00211043 | | Sigma Aldrich Fine Chemicals Biosciences | ₹ 16,036.51 | |
 | Josamycin for peak identification | Sigma Aldrich | ₹ 14,072.50 | |
| | Josamycin | Sigma Aldrich | ₹ 6,289.33 | |
 | Leucomycin V, 3-acetate 4B-(3-methylbutanoate) | Aaron Chemicals LLC | ₹ 2,310.12 - ₹ 22,416.72 | |
 | 16846-24-5 | Leucomycin V, 3-acetate 4B-(3-methylbutanoate) | A2B Chem | ₹ 3,165.72 - ₹ 18,224.28 |
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Description
- General description: Chemical structure: macrolide
- Application: Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics[1], immunomodulatory effects[2], the suppression of matrix metalloproteinase production[3] as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.[4]
- Biochem/physiol Actions: Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity.[5] It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.[6]
- Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
SAFETY INFORMATION
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
Quality Level: 200
Assay: ≥90% (HPLC)
form: powder
color: white to slightly yellow
antibiotic activity spectrum: Gram-positive bacteria
Mode of action: protein synthesis | interferes
storage temp.: 2-8°C
SMILES string: CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)OC(C)=O
InChI: 1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1
InChI key: XJSFLOJWULLJQS-NGVXBBESSA-N
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