B1793

Bafilomycin A1

from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor

Manufacturer: Sigma Aldrich

CAS Number: 88899-55-2

Select a Size

Pack Size SKU Availability Price
2 μG B1793-2-μG In Stock ₹ 11,939.98
10 μG B1793-10-μG In Stock ₹ 31,468.28

B1793 - 2 μG

₹ 11,939.98

In Stock

Quantity

1

Base Price: ₹ 11,939.98

GST (18%): ₹ 2,149.196

Total Price: ₹ 14,089.176

product name

Bafilomycin A1 from Streptomyces griseus, ≥90% (HPLC)

Quality Level

300

Assay

≥90% (HPLC)

form

film

antibiotic activity spectrum

fungi

Mode of action

DNA synthesis | interferesenzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C

InChI

1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key

XDHNQDDQEHDUTM-JQWOJBOSSA-N

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Description

  • General description: Chemical structure: macrolide
  • Application: Bafilomycin A1 has been used:as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytes[1]as a vacuolar-type H+ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cells[2]as a vacuolar-type H+ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells[3]
  • Biochem/physiol Actions: A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
  • Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

SAFETY INFORMATION

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Show Difference

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Sigma Aldrich

B1793

from Streptomyces griseus, ≥90% (HP...


product name:
Bafilomycin A1 from Streptomyces griseus, ≥90% (HPLC)

Quality Level:
300

Assay:
≥90% (HPLC)

form:
film

antibiotic activity spectrum:
fungi

Mode of action:
DNA synthesis | interferesenzyme | inhibits

storage temp.:
−20°C

SMILES string:
CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C

InChI:
1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key:
XDHNQDDQEHDUTM-JQWOJBOSSA-N

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NC(=O)OCc1ccccc1

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1S/C8H9NO2/c9-8(10)11-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)

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PUJDIJCNWFYVJX-UHFFFAOYSA-N

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