Interleukin-2 human

Description

• General description: Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27.[1] IL-2 is originally called as T cell growth factor.[2]
• Application: Interleukin-2 human has been used:in the stimulation of natural killer cells[3]to study its ability to stimulate lymphocyte growth and prevent apoptosis[4]as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus[5]
• Biochem/physiol Actions: Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages.[1] It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease.[6] IL-2 is associated with apoptosis and thus, possesses antitumor response.[7] It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.[1]
• Physical form: Lyophilized, 0.2 μm filtered, no additives.
• Analysis Note: The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.