SRP3124
Neurturin human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Manufacturer: Sigma Aldrich
Synonym(S): NRTN, NTN
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 20 μG | SRP3124-20-μG | In Stock | ₹ 34,943.10 |
SRP3124 - 20 μG
In Stock
Quantity
1
Base Price: ₹ 34,943.10
GST (18%): ₹ 6,289.758
Total Price: ₹ 41,232.858
biological source
human
recombinant
expressed in E. coli
Assay
≥98% (HPLC)≥98% (SDS-PAGE)
form
lyophilized
mol wt
11.8 kDa
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
Q99748
Description
- General description: Neurturin (NTN) is a disulfide-linked homodimer neurotrophic factor structurally related to glial cell derived neurotrophic factor (GDNF), artemin, and persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.[1][2] The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8kDa polypeptide monomers (206 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
- Biochem/physiol Actions: Neurturin (NTN) signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2. NTN modulates spermatogenesis, kidney morphogenesis and controls smooth muscle of penile blood vessels and several intrapelvic organs.[3][4]
- Sequence: MARLGARPCG LRELEVRVSE LGLGYASDET VLFRYCAGAC EAAARVYDLG LRRLRQRRRL RRERVRAQPC CRPTAYEDEV SFLDAHSRYH TVHELSAREC ACV
- Physical form: Lyophilized from 10 mM Sodium Citrate, pH 4.0.
- Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
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biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
mol wt: 11.8 kDa
packaging: pkg of 20 μg
technique(s): cell culture | mammalian: suitable
impurities: <0.1 EU/μg endotoxin, tested
color: white to off-white
UniProt accession no.: Q99748
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
mol wt:
11.8 kDa
packaging:
pkg of 20 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white to off-white
UniProt accession no.:
Q99748
biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
mol wt: 13.6 kDa
packaging: pkg of 10 μg
technique(s): cell culture | mammalian: suitable
impurities: <0.1 EU/μg endotoxin, tested
color: white to off-white
UniProt accession no.: __
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
mol wt:
13.6 kDa
packaging:
pkg of 10 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white to off-white
UniProt accession no.:
__
biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
mol wt: 14.0 kDa
packaging: pkg of 10 μg
technique(s): cell culture | mammalian: suitable
impurities: <0.1 EU/μg endotoxin, tested
color: white to off-white
UniProt accession no.: __
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
mol wt:
14.0 kDa
packaging:
pkg of 10 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white to off-white
UniProt accession no.:
__
biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
mol wt: 23.9 kDa
packaging: pkg of 10 μg
technique(s): cell culture | mammalian: suitable
impurities: <0.1 EU/μg endotoxin, tested
color: white to off-white
UniProt accession no.: __
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
mol wt:
23.9 kDa
packaging:
pkg of 10 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white to off-white
UniProt accession no.:
__