SRP6053
ProBDNF human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Manufacturer: Sigma Aldrich
Synonym(S): Abrineurin, BDNF, Brain-derived neurotrophic factor
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 μG | SRP6053-10-μG | In Stock | ₹ 25,752.68 |
SRP6053 - 10 μG
In Stock
Quantity
1
Base Price: ₹ 25,752.68
GST (18%): ₹ 4,635.482
Total Price: ₹ 30,388.162
biological source
human
recombinant
expressed in E. coli
Assay
≥95% (HPLC)≥95% (SDS-PAGE)
form
lyophilized
mol wt
~52 kDa
packaging
pkg of 10 μg
NCBI accession no.
P23560
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BDNF(627)
Description
- General description: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors.[1][2] The precursor form of brain-derived neurotrophic factor (pro-BDNF) undergoes post-translational cleavage to form mature BDNF (mBDNF). The gene encoding this protein is localized on human chromosome 11p14.1.[3][4]
- Biochem/physiol Actions: Precursor form of brain-derived neurotrophic factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) (2) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the tropomyosin-related kinase B (TrkB) kinase receptor and promotes the survival, growth and differentiation of neurons.[1] As proneurotrophins and mature neurotrophins elicit opposite biological effects, pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
- Physical form: Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 250 mM NaCl, pH 7.2.
- Preparation Note: Centrifuge the vial prior to opening.
- Reconstitution: Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/mL.). This can further be diluted to other aqueous buffers.
- Other Notes: Recombinant Human precursor form of Brain-derived neurotrophic factor produced in E. coli is a non-glycosylated polypeptide chain containing 2X229 amino acids as a homodimer and having a molecular mass of 52 kDa. The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Met-Lys-Glu.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
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biological source: human
recombinant: expressed in E. coli
Assay: ≥95% (HPLC)≥95% (SDS-PAGE)
form: lyophilized
mol wt: ~52 kDa
packaging: pkg of 10 μg
NCBI accession no.: P23560
shipped in: wet ice
storage temp.: −20°C
Gene Information: human ... BDNF(627)
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥95% (HPLC)≥95% (SDS-PAGE)
form:
lyophilized
mol wt:
~52 kDa
packaging:
pkg of 10 μg
NCBI accession no.:
P23560
shipped in:
wet ice
storage temp.:
−20°C
Gene Information:
human ... BDNF(627)
biological source: human
recombinant: expressed in E. coli
Assay: ≥95% (HPLC)≥95% (SDS-PAGE)
form: lyophilized
mol wt: ~25 kDa
packaging: pkg of 10 μg
NCBI accession no.: P01138
shipped in: wet ice
storage temp.: −20°C
Gene Information: human ... NGF(4803)
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥95% (HPLC)≥95% (SDS-PAGE)
form:
lyophilized
mol wt:
~25 kDa
packaging:
pkg of 10 μg
NCBI accession no.:
P01138
shipped in:
wet ice
storage temp.:
−20°C
Gene Information:
human ... NGF(4803)
biological source: human
recombinant: expressed in HEK 293 cells
Assay: ≥95% (SDS-PAGE)
form: lyophilized
mol wt: 36 kDa (monomer, glycosylated)
packaging: pkg of 10 μg
NCBI accession no.: P01588
shipped in: dry ice
storage temp.: __
Gene Information: __
biological source:
human
recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
form:
lyophilized
mol wt:
36 kDa (monomer, glycosylated)
packaging:
pkg of 10 μg
NCBI accession no.:
P01588
shipped in:
dry ice
storage temp.:
__
Gene Information:
__
biological source: human
recombinant: expressed in HEK 293 cells
Assay: ≥95% (SDS-PAGE)
form: lyophilized
mol wt: 22 kDa (monomer, non-glycosylated)
packaging: pkg of 10 μg
NCBI accession no.: P01241
shipped in: __
storage temp.: __
Gene Information: __
biological source:
human
recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
form:
lyophilized
mol wt:
22 kDa (monomer, non-glycosylated)
packaging:
pkg of 10 μg
NCBI accession no.:
P01241
shipped in:
__
storage temp.:
__
Gene Information:
__