RANK Ligand/TRANCE human

Description

• General description: Tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11) is also known as receptor activator of nuclear factor-κB ligand (RANKL). It is a type II transmembrane signaling receptor. It has a molecular weight of around 35kDa. This protein contains an amino-terminal intracellular tail and a carboxy-terminal extracellular region, that bears a connecting stalk and a receptor-binding domain.[1][2] Tnfsf11 is located on human chromosome 13q14.11.[3]
• Application: RANK Ligand/TRANCE human can be used in in vitro osteoclastogenic assays for osteoclast differentiation.[4]
• Biochem/physiol Actions: RANK Ligand (receptor activator of NF-kB ligand (RANKL) also referred to as TNF-related activation induced cytokines (TRANCE) or osteoprotegerin ligand is a protein that belongs to tumor necrosis factor (TNF) family. It stimulates the mature dendritic cells and induces the cytokine production.[6] RANKL also facilitates bone remodelling and possess an angiogenic activity.[7]
• Physical form: Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS and 500 mM NaCl, pH 6.5, with 50 μg BSA per 1 μg as a carrier protein.
• Analysis Note: The biological activity is measured by its ability to induce osteoclast differentiation on mouse splenocytes.