24(R/S),25-epoxycholesterol

Name: 24(R/S),25-epoxycholesterol | Sigma Aldrich | Chemikart
Brand: Chemikart

Manufacturer: Sigma Aldrich

CAS Number: 72542-49-5

Synonym(S): Cholest-5-en-3-ol, 24,25-epoxy-, (3β)-

Pack Size	SKU	Availability	Price
1 MG	700037P-1-MG	In Stock	₹ 51,278.03

700037P - 1 MG

₹ 51,278.03

In Stock

Quantity

Base Price: ₹ 51,278.03

GST (18%): ₹ 9,230.045

Total Price: ₹ 60,508.075

powder

pkg of 1 × 1 mg (700037P-1mg)

Avanti Polar Lipids

dry ice

−20°C

Other Options

Image	Product Name	Manufacturer	Price Range
	Avanti Polar Lipids 24(R/S),25-epoxycholesterol \| 72542-49-5 \| MFCD22416724 \| 1mg	Avanti Polar Lipids	₹ 44,867.66
	72542-49-5 \| (3S,8S,9S,10R,13R,14S,17R)-17-((R)-4-((R)-3,3-Dimethyloxiran-2-yl)butan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol	A2B Chem	₹ 12,235.08

Application: 24(R/S),25-epoxycholesterol has been used as liver X receptor ligand in breast cancer cell lines.[1][2]
Biochem/physiol Actions: 24(R/S),25-epoxycholesterol (24(R/S),25-EC) is a side chain substituted cholesterol. It is an effective activator of liver X receptor (LXR) transcription.[2] 24R and 24S epimers of epoxycholesterol inhibit cholesterol synthesis from 24,25-dihydrolanosterol.[3] The levels of 24(R/S),25-EC is elevated in gastric carcinoma and may also inhibit gastric tumor invasion.[4] 24(R/S),25-EC regulates gastric epithelial function and also may modulates the phosphatidylinositol 3-kinase - protein kinase B (PI3K/AKT) signaling.[5]
Packaging: 5 mL Amber Glass Screw Cap Vial (700037P-1mg)