Description

• General description: Campesterol-d6 is the deuterated form of campesterol. It is a plant sterol, which is an analog of cholesterol[1] and a brassinosteroid (BR) precursor. The enzyme diminute/dwarf1 mediates the synthesis of campesterol from 24-methylenecholesterol.[2] Campesterol possesses methyl group at C-24 position of the side chain in the cholesterol structure.[3] It is not synthesized in mammanls and is diet derived[4]
• Application: Campesterol-d6 has been used as a deuterium-labeled internal standard in gas chromatography (GC)–triple quadrupole mass spectrometry[5] and liquid chromatography-high resolution mass spectrometry (LC-HRMS).[6]
• Biochem/physiol Actions: Campesterol reduces the levels of chylomicron.[1] The d6-campesterol along with d6-sitosterol and d6-cholesterol has been used in the transport blood-brain barrier studies in human brain endothelial hCMEC/D3 monolayer cells.[4] Campesterol is a biomarker for tracking cholesterol synthesis and absorption.[6] Campesterol like cholesterol is catabolized by intestinal microbes. It possess chemopreventive functionality prostate and breast tumors. Campesterol also has antiangiogenic property and may be useful in treating disorders related to angiogenesis.[7]
• Packaging: 5 mL Amber Glass Screw Cap Vial (700092P-1mg)