V4140
Virginiamycin S1
≥99% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 23152-29-6
Synonym(S): dihydro virginiamycin S1, Antibiotic 899, Staphylomycin S
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | V4140-5-MG | In Stock | ₹ 54,980.18 |
V4140 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 54,980.18
GST (18%): ₹ 9,896.432
Total Price: ₹ 64,876.612
biological source
Streptomyces virginiae
Quality Level
100
Assay
≥99% (HPLC)
form
solid
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white
antibiotic activity spectrum
Gram-positive bacteria
Mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]3CC(=O)CCN3C(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H]5CCCN5C1=O)c6ccccc6
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Description
- General description: Chemical structure: macrolide
- Application: The antibiotic virginiamycin is produced by Streptomyces virginiae and is a member of the virginiamycin family. Each member is produced as a mixture of two structurally different compounds that exhibit synergistic antibacterial activity. There are two groups: virginiamycin M1 (VM1) and virginiamycin S (VS). VS is a cyclic hexadepsipeptide. VS and VM1 are both used to inhibit protein synthesis since they are bacteriostatic. When used in combination they are more effective. Virginiamycin is used as a performance promoter in animal husbandry. It is chemically modified to make therapeutic drugs such as quinupristin and dalfopristin[1][2].
- Biochem/physiol Actions: Virginiamycin S inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. It inactivates the 50S ribosome. VS is a cyclic hexadepsipeptide containing a nonproteinogenic amino acid, Lphenylglycine (L-pheGly), in its core structure. The visG gene is required for VS biosynthesis. Nonribosomal peptide synthetase (NRPS) may be involved in VS biosynthesis. Virginiamycin S is active against Gram-positive bacteria[1].
- Preparation Note: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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biological source: Streptomyces virginiae
Quality Level: 100
Assay: ≥99% (HPLC)
form: solid
storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
color: white
antibiotic activity spectrum: Gram-positive bacteria
Mode of action: protein synthesis | interferes
storage temp.: −20°C
SMILES string: CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]3CC(=O)CCN3C(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H]5CCCN5C1=O)c6ccccc6
biological source:
Streptomyces virginiae
Quality Level:
100
Assay:
≥99% (HPLC)
form:
solid
storage condition:
(Keep container tightly closed in a dry and well-ventilated place.)
color:
white
antibiotic activity spectrum:
Gram-positive bacteria
Mode of action:
protein synthesis | interferes
storage temp.:
−20°C
SMILES string:
CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]3CC(=O)CCN3C(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H]5CCCN5C1=O)c6ccccc6
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